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Ny publikation: Serum neutralization of Omicron BA.5, BA.2 and BA.1 in triple vaccinated kidney transplant recipients

In conclusion, our results indicate that the KTRs’ neutralization capacity against the currently dominating Omicron BA.5 approximates their ability to neutralize earlier Omicron subvariants. Moreover, a considerable proportion of the KTRs show a relatively robust neutralization response against all tested Omicron subvariants after the first BNT162b2 booster. In addition, we observed a tendency toward a division of KTRs into low responders and high responders, with the first group, despite a general increase in Ab levels, still being unable to neutralize recent SARS-CoV-2 variants. Additional boosters including the now available bivalent mRNA vaccines may increase Ab levels and affinities even in this group, thus providing an important fundamental level of protection against currently circulating SARS-CoV-2 strains.
Redaktionen afsluttet: 07.02.2023