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Long Life Family Study

Are Advances in Survival among the Oldest Old Seen across the Spectrum of Health and Functioning?

Thinggaard M, Jeune B, Osler M, Vaupel JW, McGue M, Christensen K.

J Gerontol A Biol Sci Med Sci2020 Nov;75(12):2354-2360.  PubMed


β-adrenoreceptors and the risk of Parkinson's disease.

Hopfner F, Höglinger GU, Kuhlenbäumer G, Pottegaard A, Wod M, Christensen K, Tanner CM, Deuschl G.

Lancet Neurol2020 Mar;19(3):247-254. PubMed

Body height in young adult men and risk of dementia later in adult life.

Jørgensen TSH, Okholm GT, Christensen K, Sørensen TI, Osler M.

Elife. 2020 Feb 11;9. pii: e51168. PubMed


Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies.

Arbeev KG, Verhulst S, Steenstrup T, Kark JD, Bagley O, Kooperberg C, Reiner AP, Hwang SJ, Levy D, Fitzpatrick AL, Christensen K, Yashin AI, Aviv A.

JAMA Netw Open. 2020 Feb 5;3(2):e200023. PubMed


Age-dependent DNA methylation patterns on the Y chromosome in elderly males.
Lund JB, Li S, Christensen K, Mengel-From J, Soerensen M, Marioni RE, Starr J, Pattie A, Deary IJ, Baumbach J, Tan Q.
Aging Cell. 2020 Feb;19(2):e12907. Pubmed abstract


Parallel progress in perceived age and life expectancy.

Steiner UK, Larsen LA, Christensen K.
J Gerontol A Biol Sci Med Sci. 2020;75(2):333-339. Pubmed abstract 


Gene-lifestyle interactions in longevity

Lindahl-Jacobsen R & Christensen K.
I: Fernández-Ballesteros R, Benetos A & Robine J-M (red.): Cambridge Handbook of Successful Aging, s. 91-109; Cambridge University Press, New York, 2019.


Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies.
Mengel-From J, Svane AM, Pertoldi C, Kristensen TN, Loeschcke V, Skytthe A, Christensen K, Lindahl-Jacobsen R, Hjelmborg J, Christiansen L.
J Gerontol A Biol Sci Med Sci. 2019 Nov;74(12):1853-1860. Pubmed abstract

Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength.

Soerensen M, Li W, Debrabant B, Nygaard M, Mengel-From J, Frost M, Christensen K, Christiansen L, Tan Q.

Biogerontology. 2019 Oct;20(5):627-647. Pubmed abstract


Declining cancer incidence at the oldest ages: Hallmark of aging or lower diagnostic activity?

Pedersen JK, Rosholm JU, Ewertz M, Engholm G, Lindahl-Jacobsen R, Christensen K.

J Geriatr Oncol. 2019 Sep;10(5):792-798. Pubmed abstract


Epigenome-wide association study of depression symptomatology in elderly monozygotic twins.

Starnawska A, Tan Q, Soerensen M, McGue M, Mors O, Børglum AD, Christensen K, Nyegaard M, Christiansen L.

Transl Psychiatry. 2019 Sep;9(1):214. Pubmed abstract


A meta-analysis of genome-wide association studies identifies multiple longevity genes.

Deelen J, Nygaard M, Christensen K, Christiansen L, Debrabant B, Vaupel JW, Murabito JM et al.

Nat Commun. 2019 Aug;10(1):3669. Pubmed abstract


Optimizing the Feasibility and Scalability of a Geriatric Surgery Quality Improvement Initiative.
Hornor MA, Tang VL, Berian J, Robinson TN, Coleman J, Katlic MR, Rosenthal RA, Christensen K, Baker T, Finlayson E, Lagoo-Deenadaayalan SA, Ko CY, Russell MM.
J Am Geriatr Soc. 2019 May; 67(5):1074-1078. Pubmed abstract 

A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity.

Marron MM, Miljkovic I, Boudreau RM, Christensen K, Feitosa MF, Lee JH, Sebastiani P, Thyagarajan B, Wojczynski MK, Zmuda JM, Newman AB; Long Life Family Study.

Metabolism. 2019 May;94:28-38. Pubmed abstract

A Cohort Comparison of Lifespan After Age 100 in Denmark and Sweden: Are Only the Oldest Getting Older?

Medford A, Christensen K, Skytthe A, Vaupel JW.

Demography. 2019 Apr;56(2):665-677. Pubmed abstract


Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers.
Skytthe A, Harris JR, Czene K, Mucci L, Adami HO, Christensen K, Hjelmborg J, Holm NV, Nilsen TS, Kaprio J, Pukkala E.
Twin Res Hum Genet. 2019 Apr;22(2):99-107Pubmed abstract


Trends in Hospital Deaths in Denmark from 1980 to 2014, at Ages 50 and Older.

Carollo A, Verdiell NC, Hale JM, Andersen-Ranberg K, Lindahl-Jacobsen R, Oksuzyan A.

J Am Geriatr Soc. 2019 Mar;67(3):471-476. Pubmed abstract


Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts.

Jylhävä J, Hjelmborg J, Soerensen M, Munoz E, Tan Q, Kuja-Halkola R, Mengel-From J, Christensen K, Christiansen L, Hägg S, Pedersen NL, Reynolds CA.

EBioMedicine. 2019 Feb;40:710-716. Pubmed abstract


Hearing loss, cognitive ability, and dementia in men age 19-78 years.

Osler M, Christensen GT, Mortensen EL, Christensen K, Garde E, Rozing MP.

Eur J Epidemiol. 2019 Feb;34(2):125-130. Pubmed abstract  


Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.

Kraja AT, Christensen K et al.

Am J Hum Genet. 2019 Jan;104(1):112-138. Pubmed abstract


Independent associations of TOMM40 and APOE variants with body mass index.
Kulminski AM, Loika Y, Culminskaya I, Huang J, Arbeev KG, Bagley O, Feitosa MF, Zmuda JM, Christensen K, Yashin AI; Long Life Family Study Research Group.
Aging Cell. 2019 Feb;18(1):e12869. Pubmed abstract 


DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns.

Lund JB, Li S, Baumbach J, Svane AM, Hjelmborg J, Christiansen L, Christensen K, Redmond P, Marioni RE, Deary IJ, Tan Q.

Clin Epigenetics. 2019 Feb;11(1):23. Pubmed abstract


Diagnosing heart failure in centenarians.

Rasmussen SH, Andersen-Ranberg K, Dahl JS, Nybo M, Jeune B, Christensen K, Gill S.

J Geriatr Cardiol. 2019 Jan;16(1):1-11. Pubmed abstract


APOE Alleles and Extreme Human Longevity.

Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT.

J Gerontol A Biol Sci Med Sci. 2019 Jan;74(1):44-51. Pubmed abstract

Last years of life

How can treatment be improved in the last years of our life? Should we change our preconceptions about the well-being of today's oldest old?

Are we doing well?

Research in the health, treatment and well-being of the oldest old

Velux foundation

Department of Public Health

  • J.B Winsløwsvej 9b, st. t.v.
  • Odense C - DK-5000
  • Phone: +45 6550 4088

Last Updated 31.05.2021