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Publikationsliste: LLFS

Evaluation of the Bidirectional Relations of Perceived Physical Fatigability and Physical Activity on Slower Gait Speed.
Qiao YS, Gmelin T, Renner SW, Boudreau RM, Martin S, Wojczynski MK, Christensen K, Andersen SL, Cosentino S, Santanasto AJ, Glynn NW.J Gerontol A Biol Sci Med Sci. 2020 Nov. Pubmed abstract  
[Epud ahead of print]

Circulating Procollagen type III N-terminal peptide (P3NP) and Physical Function in Adults from The Long Life Family Study.
Santanasto AJ, Cvejkus RK, Wojczynski MK, Marron MM, Schupf N, Christensen K, Thyagarajan B, Zmuda JM.
J Gerontol A Biol Sci Med Sci. 2020 Aug. Pubmed abstract 
[Epub ahead of print]


Composite Measure of Physiological Dysregulation as a Predictor of Mortality: The Long Life Family Study. 

Arbeev KG, Bagley O, Ukraintseva SV, Duan H, Kulminski AM, Stallard E, Wu D, Christensen K, Feitosa MF, Thyagarajan B, Zmuda JM, Yashin AI, Arbeev KG, et al. 
Front Public Health. 2020 Mar;8:56. Pubmed abstract

Genetics of physiological dysregulation: findings from the long life family study using joint models. 
Arbeev KG, Bagley O, Ukraintseva SV, Wu D, Duan H, Kulminski AM, Stallard E, Christensen K, Lee JH, Thyagarajan B, Zmuda JM, Yashin AI.Arbeev KG, et al. 
Aging (Albany NY). 2020 Apr;12(7):5920-5947.  Pubmed abstract

Leukocyte Telomere Length Is Unrelated to Cognitive Performance Among Non-Demented and Demented Persons: An Examination of Long Life Family Study Participants.
Ashrafi A, Cosentino S, Kang MS, Lee JH, Schupf N, Andersen SL, Christensen K, Province MA, Thyagarajan B, Zmuda JM, Honig LS, Ashrafi A, et al.
J Int Neuropsychol Soc. 2020 Oct;26(9):906-917. Pubmed abstract

Mechanisms underlying familial aggregation of exceptional health and survival: A three-generation cohort study.
Christensen K, Wojczynski MK, Pedersen JK, Larsen LA, Kløjgaard S, Skytthe A, McGue M, Vaupel JW, Province MA.
Aging Cell. 2020 Oct;19(10):e13228. Pubmed abstract

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.
Feitosa MF, Lunetta KL, Wang L, Wojczynski MK, Kammerer CM, Perls T, Schupf N, Christensen K, Murabito JM, Province MA.
Atherosclerosis. 2020 Mar;297:102-110. Pubmed abstract

Epidemiology of Perceived Physical Fatigability in Older Adults: The Long Life Family Study.

LaSorda KR, Gmelin T, Kuipers AL, Boudreau RM, Santanasto AJ, Christensen K, Renner SW, Wojczynski MK, Andersen SL, Cosentino S, Glynn NW; LLFS Research Group.

J Gerontol A Biol Sci Med Sci. 2020 Sep;75(9):e81-e88. Pubmed abstract


Patterns of multi-domain cognitive aging in participants of the Long Life Family Study.
Sebastiani P, Andersen SL, Sweigart B, Du M, Cosentino S, Thyagarajan B, Christensen K, Schupf N, Perls TT.
Geroscience. 2020 Oct;42(5):1335-1350. Pubmed abstract



Independent associations of  TOMM40 and APOE variants with body mass index.
Kulminski AM, Loika Y, Culminskaya I, Huang J, Arbeev KG, Bagley O, Feitosa MF, Zmuda JM, Christensen K, Yashin AI; Long Life Family Study Research Group.
Aging Cell. 2019 Feb;18(1):e12869. Pubmed abstract


Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism.

Marron MM, Wojczynski MK, Minster RL, Boudreau RM, Sebastiani P, Cosentino S, Thyagarajan B, Ukraintseva SV, Schupf N, Christensen K, Feitosa M, Perls T, Zmuda JM, Newman AB. 

Geroscience. 2019 Aug;41(4):383-393. Pubmed abstract


A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity.

Marron MM, Miljkovic I, Boudreau RM, Christensen K, Feitosa MF, Lee JH, Sebastiani P, Thyagarajan B, Wojczynski MK, Zmuda JM, Newman AB; Long Life Family Study.

Metabolism. 2019 May;94:28-38. Pubmed abstract


APOE Alleles and Extreme Human Longevity.

Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT.

J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):44-51. Pubmed abstract



The APOE ε4 allele is associated with a reduction in FEV1/FVC in women: A cross-sectional analysis of the Long Life Family Study.

Kulminski AM, Barochia AV, Loika Y, Raghavachari N, Arbeev KG, Wojczynski MK, Thyagarajan B, Vardarajan BN, Christensen K, Yashin AI, Levine SJ.

PLoS One. 2018 Nov;13(11):e0206873. Pubmed abstract

A novel healthy blood pressure phenotype in the Long Life Family Study.
Marron MM, Singh J, Boudreau RM, Christensen K, Cosentino S, Feitosa MF, Minster RL, Perls T, Schupf N, Sebastiani P, Ukraintseva S, Wojczynski MK, Newman AB.
J Hypertens. 2018 Jan;36(1):43-53. Pubmed abstract

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.

Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Bagley O, Stallard E, Kulminski AM, Akushevich I, Fang F, Wojczynski MK, Christensen K, Newman AB, Boudreau RM, Province MA, Thielke S, Perls TT, An P, Elo I, Ukraintseva SV.

J Gerontol A Biol Sci Med Sci. 2018 Oct;73(11):1472-1481. Pubmed abstract


Age-related biomarkers  in LLFS families with exceptional cognitive abilities.
Barral S, Singh J, Fagan E, Cosentino S, Andersen-Toomey SL, Wojczynski MK, Feitosa M, Kammerer CM, Schupf N; Long Life Family Study. 
J Gerontol A Biol Sci Med Sci. 2017 Nov 9;72(12):1683-1688. Pubmed abstract


Telomere length is longer in women with late maternal age.

Fagan E, Sun F, Bae H, Elo I, Andersen SL, Lee J, Christensen K, Thyagarajan B, Sebastiani P, Perls T, Honig LS, Schupf N.
Menopause. 2017 May;24(5):497-501. Pubmed abstract

The Survival of Spouses Marrying Into Longevity-Enriched Families.
Pedersen JK, Elo IT, Schupf N, Perls TT, Stallard E, Yashin AI, Christensen K.
J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):109-114. Pubmed abstract

Assortative mating by ethnicity in longevous families. 
Sebastiani P, Gurinovich A, Bae H, Andersen SL, Perls TT. 
Front Genet. 2017 Nov 21;8:186.  Pubmed abstract

Biomarker signatures of aging.
Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT.
Aging Cell. 2017 Apr;16(2):329-338. Pubmed abstract

Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study.
Singh J, Minster RL, Schupf N, Kraja A, Liu Y, Christensen K, Newman AB, Kammerer CM.
J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1411-1416.  Pubmed abstract


Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study.
Druley TE, Wang L, Lin SJ, Lee JH, Zhang Q, Daw EW, Abel HJ, Chasnoff SE, Ramos EI, Levinson BT, Thyagarajan B, Newman AB, Christensen K, Mayeux R, Province MA.
BMC Geriatr. 2016 Apr 9;16:80. Pubmed abstract

Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study.
Kulminski AM, Raghavachari N, Arbeev KG, Culminskaya I, Arbeeva L, Wu D, Ukraintseva SV, Christensen K, Yashin AI.
Biogerontology. 2016 Nov;17(5-6):893-905. Pubmed abstract

Association Between Mortality and Heritability of the Scale of Aging Vigor in Epidemiology.
Sanders JL, Singh J, Minster RL, Walston JD, Matteini AM, Christensen K, Mayeux R, Borecki IB, Perls T, Newman AB.
J Am Geriatr Soc. 2016 Aug;64(8):1679-83. Pubmed abstract

Detection of Significant Groups in Hierarchical Clustering by Resampling.
Sebastiani P, Perls TT.
Front Genet. 2016 Aug 8;7:144. Pubmed abstract

Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study.

Sebastiani P, Thyagarajan B, Sun F, Honig LS, Schupf N, Cosentino S, Feitosa MF, Wojczynski M, Newman AB, Montano M, Perls TT. 
J Am Geriatr Soc. 2016 Nov;64(11):e189-e194. Pubmed abstract


Are members of long-lived families healthier than their equally long-lived peers? Evidence from the Long Life Family Study.
Ash AS, Kroll-Desrosiers AR, Hoaglin DC, Christensen K, Fang H, Perls TT.
J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):971-6. Pubmed abstract

Heritability of telomere length in a study of long-lived families.
Honig LS, Kang MS, Cheng R, Eckfeldt JH, Thyagarajan B, Leiendecker-Foster C, Province MA, Sanders JL, Perls T, Christensen K, Lee JH, Mayeux R, Schupf N.
Neurobiol Aging. 2015 Oct;36(10):2785-90. Pubmed abstract

Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of heart, cancer, and neurodegenerative disorders: Insights on mechanisms from the Long Life Family Study.
Kulminski A, Arbeev K, Culminskaya I, Ukraintseva S, Stallard E, Province M, Yashin AI.
Rejuvenation Res. 2015 Apr;18(2):128-35. Pubmed abstract

Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index.
Minster RL, Sanders JL, Singh J, Kammerer CM, Barmada MM, Matteini AM, Zhang Q, Wojczynski MK, Daw EW, Brody JA, Arnold AM, Lunetta KL, Murabito JM, Christensen K, Perls TT, Province MA, Newman AB.
J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):1003-8. Pubmed abstract

Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.
Pedersen JK, Skytthe A, McGue M, Honig LS, Franceschi C, Kirkwood TB, Passarino G, Slagboom PE, Vaupel JW, Christensen K.
Ann Epidemiol. 2015 Aug;25(8):569-574.e3. Pubmed abstract

Association of Aging-Related Endophenotypes With Mortality in 2 Cohort Studies: the Long Life Family Study and the Health, Aging and Body Composition Study.
Singh J, Schupf N, Boudreau R, Matteini AM, Prasad T, Newman AB, Liu Y, Christensen K, Kammerer CM.
Am J Epidemiol. 2015 Dec 1;182(11):926-35. Pubmed abstract

Burden of disease variants in participants of the long life family study.
Stevenson M, Bae H, Schupf N, Andersen S, Zhang Q, Perls T, Sebastiani P.
Aging (Albany NY). 2015 Feb;7(2):123-32. Pubmed abstract


Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: The Long Life Family Study (LLFS).
An P, Miljkovic I, Thyagarajan B, Kraja AT, Daw EW, Pankow JS, Selvin E, Kao WH, Maruthur NM, Nalls MA, Liu Y, Harris TB, Lee JH, Borecki IB, Christensen K, Eckfeldt JH, Mayeux R, Perls TT, Newman AB, Province MA.
Metabolism. 2014 Apr;63(4):461-8. Pubmed abstract

Common Genetic Variants on 6q24 Associated With Exceptional Episodic Memory Performance in the Elderly.
Barral S, Cosentino S, Christensen K, Newman AB, Perls TT, Province MA, Mayeux R; for the Long Life Family Study.
JAMA Neurol. 2014 Dec;71(12):1514-9. Pubmed abstract

Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol.
Feitosa MF, Wojczynski MK, Straka R, Kammerer CM, Lee JH, Kraja AT, Christensen K, Newman AB, Province MA, Borecki IB. 
Front Genet.
2014 Jun 3;5:159. Pubmed abstract

Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.
Kulminski AM, Arbeev KG, Culminskaya I, Arbeeva L, Ukraintseva SV, Stallard E, Christensen K, Schupf N, Province MA, Yashin AI.
PLoS Genet. 2014 Jan 30;10(1):e1004141. Pubmed abstract

Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
Lee JH, Cheng R, Honig LS, Feitosa M, Kammerer CM, Kang MS, Schupf N, Lin SJ, Sanders JL, Bae H, Druley T, Perls T, Christensen K, Province M, Mayeux R.
Front Genet. 2014 Jan 17;4:310. eCollection 2013. Pubmed abstract

Heritability of and Mortality Prediction With a Longevity Phenotype: The Healthy Aging Index
Sanders JL, Minster RL, Barmada MM, Matteini AM, Boudreau RM, Christensen K, Mayeux R, Borecki IB, Zhang Q, Perls T, Newman AB.
J Gerontol A Biol Sci Med Sci. 2014 Apr;69(4):479-85. Pubmed abstract

Hierarchical linear modeling of longitudinal pedigree data for genetic association analysis.
Tan Q, B Hjelmborg JV, Thomassen M, Jensen AK, Christiansen L, Christensen K, Zhao JH, Kruse TA.
BMC Proc. 2014 Jun;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S82. Pubmed abstract

Genetic variants associated with lung function: the long life family study.
Thyagarajan B, Wojczynski M, Minster RL, Sanders J, Barral S, Christiansen L, Barr RG, Newman A; CHARGE consortium, SpiroMeta consortium.
Respir Res. 2014 Nov 1;15(1):134. Pubmed abstract


Personality factors in the Long Life Family Study
Andersen SL, Sun JX, Sebastiani P, Huntly J, Gass JD, Feldman L, Bae H, Christiansen L, Perls TT.
J Gerontol B Psychol Sci Soc Sci. 2013 Sep;68(5):739-49. Pubmed abstract

Genome-wide association study of personality traits in the long life family study.
Bae HT, Sebastiani P, Sun JX, Andersen SL, Daw EW, Terracciano A, Ferrucci L, Perls TT.
Front Genet. 2013 May 8;4:65. eCollection 2013. Pubmed abstract

Exceptional memory performance in the Long Life Family Study
Barral S, Cosentino S, Costa R, Andersen SL, Christensen K, Eckfeldt JH, Newman AB, Perls TT, Province MA, Hadley EC, Rossi WK, Mayeux R; for the Long Life Family Study.
Neurobiol Aging. 2013 Nov;34(11):2445-8. Pubmed abstract

Reduced prevalence of cognitive impairment in families with exceptional longevity
Cosentino S, Schupf N, Christensen K, Andersen SL, Newman A, Mayeux R.
JAMA Neurol. 2013 Jul 1;70(7):867-74. Pubmed abstract

Age validation in the long life family study through a linkage to early-life census records
Elo IT, Mykyta L, Sebastiani P, Christensen K, Glynn NW, Perls T.
J Gerontol B Psychol Sci Soc Sci. 2013 Jul;68(4):580-5. Pubmed abstract

Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children
Kulminski AM, Arbeev KG, Christensen K, Stallard E, Miljkovic I, Barmada M, Yashin AI.
J Gerontol A Biol Sci Med Sci. 2013 Jul;68(7):760-8. Pubmed abstract

Apolipoprotein E and familial longevity
Schupf N, Barral S, Perls T, Newman A, Christensen K, Thyagarajan B, Province M, Rossi WK, Mayeux R.
Neurobiol Aging. 2013 Apr;34(4):1287-91. Pubmed abstract

Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study.
Sebastiani P, Sun FX, Andersen SL, Lee JH, Wojczynski MK, Sanders JL, Yashin A, Newman AB, Perls TT.
Front Public Health. 2013 Sep 30;1:38. Pubmed abstract


Cognitive function in families with exceptional survival
Barral S, Cosentino S, Costa R, Matteini A, Christensen K, Andersen SL, Glynn NW, Newman AB, Mayeux R.
Neurobiol Aging. 2012 Mar;33(3):619.e1-7. Pubmed abstract

Population-based rare variant detection via pooled exome or custom hybridization capture with or without individual indexing
Ramos E, Levinson BT, Chasnoff S, Hughes A, Young AL, Thornton K, Li A, Vallania FL, Province M, Druley TE.
BMC Genomics. 2012 Dec 6;13:683. Pubmed abstract


Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits
Kulminski AM, Arbeev KG, Christensen K, Mayeux R, Newman AB, Province MA, Hadley EC, Rossi W, Perls TT, Elo IT, Yashin AI.
Mech Ageing Dev. 2011 Apr;132(4):195-201. Pubmed abstract

Health and function of participants in the Long Life Family Study: A comparison with other cohorts
Newman AB, Glynn NW, Taylor CA, Sebastiani P, Perls TT, Mayeux R, Christensen K, Zmuda JM, Barral S, Lee JH, Simonsick EM, Walston JD, Yashin AI, Hadley E.
Aging (Albany NY). 2011 Jan;3(1):63-76. Pubmed abstract


Heritability estimates of endophenotypes of long and health life: the Long Life Family Study
Matteini AM, Fallin MD, Kammerer CM, Schupf N, Yashin AI, Christensen K, Arbeev KG, Barr G, Mayeux R, Newman AB, Walston JD.
J Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1375-9. Pubmed abstract

"Predicting" parental longevity from offspring endophenotypes: data from the Long Life Family Study (LLFS).
Yashin AI, Arbeev KG, Kulminski A, Borecki I, Christensen K, Barmada M, Hadley E, Rossi W, Lee JH, Cheng R, Elo IT.
Mech Ageing Dev. 2010 Mar;131(3):215-22. Pubmed abstract


A family longevity selection score: ranking sibships by their longevity, size, and availability for study.
Sebastiani P, Hadley EC, Province M, Christensen K, Rossi W, Perls TT, Ash AS.
Am J Epidemiol. 2009 Dec 15;170(12):1555-62. Pubmed abstract


A novel sampling design to explore gene-longevity associations: the ECHA study.
De Rango F, Dato S, Bellizzi D, Rose G, Marzi E, Cavallone L, Franceschi C, Skytthe A, Jeune B, Cournil A, Robine JM, Gampe J, Vaupel JW, Mari V, Feraco E, Passarino G, Novelletto A, De Benedictis G.
Eur J Hum Genet. 2008 Feb;16(2):236-42. Pubmed abstract

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Sidst opdateret: 24.03.2021