2025
SNP rs6543176 is associated with extreme human longevity but increased risk for cancer
Gurinovich A, Song Z, Bae H, Leshchyk A, Li M, Lords H, Andersen SL, Nygaard M, Christensen K, Daw EW, Arbeev KG, Brent MR, Perls TT, Sebastiani P.
Geroscience. 2025 Jun;47(3):3163-3168.
Genetic and environmental influences on alcohol consumption in middle to late life
Gustavson DE, Bell TR, Buchholz EJ, Zellers S, Luczak SE, Reynolds CA, Finch BK, Nygaard M, Catts VS, Christensen K, Finkel D, Kremen WS, Latvala A, Martin NG, McGue M, Mewton L, Mosing MA, Panizzon MS, Plassman BL, Kaprio J, Gatz M, Franz CE; IGEMS Consortium.
Psychol Addict Behav. 2025.
Emerging uncertainty on the anti-aging potential of metformin
Keys MT, Hallas J, Miller RA, Suissa S, Christensen K.
Ageing Res Rev. 2025 Jun:102817.
A lifespan perspective on cognitive reserve and risk for dementia
Kremen WS, Ericsson M, Gatz M, Karlsson IK, Nygaard M, Pedersen NL, Panizzon MS.
Alzheimers Dement. 2025 Jun;21(6):e70176.
Robust serum proteomic signatures of APOE2
Sebastiani P, Reed E, Chandler KB, Lopez P, Lords H, Bae H, Costello CE, Au M, Deng LL, Li M, Xiang Q, Noh H, Pflieger L, Funk C, Rappaport N, Nygaard M, Short MI, Brent M, Monti S, Andersen SL, Perls TT.
bioRxiv [Preprint]. 2025 May:2025.05.24.655950.
2024
Discovery of genomic and transcriptomic pleiotropy between kidney function and soluble receptor for advanced glycation end products using correlated meta-analyses: The Long Life Family Study
Feitosa MF, Lin SJ, Acharya S, Thyagarajan B, Wojczynski MK, Kuipers AL, Kulminski A, Christensen K, Zmuda JM, Brent MR, Province MA.
Aging Cell. 2024 Oct;23(10):e14261.
Age and sex differences in the genetic architecture of measures of subjective health: relationships with physical health, depressive symptoms, and episodic memory
Finkel D, Gatz M, Franz CE, Catts VS, Christensen K, Kremen W, Nygaard M, Plassman BL, Sachdev PS, Whitfield K, Pedersen NL.
J Gerontol B Psychol Sci Soc Sci. 2024 Jun;79(6):gbae062.
End of life events and causes of death in Danish long-lived siblings: Reduced dementia risk compared to sporadic long-livers
Galvin A, Pedersen JK, Arbeev KG, Feitosa MF, Ukraintseva S, Yao S, Newman AB, Christensen K.
J Alzheimers Dis. 2024;99(4):1397-1407.
The Protective Effect of Familial Longevity Persists After Age 100: Findings From the Danish National Registers
Galvin A, Pedersen JK, Wojczynski MK, Ukraintseva S, Arbeev K, Feitosa M, Province MA, Christensen K.
J Gerontol A Biol Sci Med Sci. 2024 Jan;79(1).
Cognitively high-performing oldest old individuals are physically active and have strong motor skills-A study of the Danish 1905 and 1915 birth cohorts
Hermansen M, Nygaard M, Tan Q, Jeune B, Semkovska M, Christensen K, Thinggaard M, Mengel-From J.
Arch Gerontol Geriatr. 2024 Jul:122:105398.
Developmental origins of exceptional health and survival: A four-generation family cohort study
Keys MT, Pedersen DA, Larsen PS, Kulminski A, Feitosa MF, Wojczynski M, Province M, Christensen K.
medRxiv [Preprint]. 2024 May.
Markers of mitochondrial function and DNA repair associated with physical function in centenarians
Sanchez-Roman I, Ferrando B, Holst CM, Mengel-From J, Rasmussen SH, Thinggaard M, Bohr, VA, Christensen K, Stevnsner T.
Biomolecules. 2024 Jul;14(8):909.
Whole genome linkage and association analyses identify DLG associated protein-1 as a novel positional and biological candidate gene for muscle strength: The Long Life Family Study
Santanasto AJ, Acharya S, Wojczynski MK, Cvejkus RK, Lin S, Brent MR, Anema JA, Wang L, Thyagarajan B, Christensen K, Daw EW, Zmuda JM.
J Gerontol A Biol Sci Med Sci. 2024 Aug;79(8):glae144.
Metabolite signatures of chronological age, aging, survival, and longevity
Sebastiani P, Monti S, Lustgarten MS, Song Z, Ellis D, Tian Q, Schwaiger-Haber M, Stancliffe E, Leshchyk A, Short MI, Ardisson Korat AV, Gurinovich A, Karagiannis T, Li M, Lords HJ, Xiang Q, Marron MM, Bae H, Feitosa MF, Wojczynski MK, O'Connell JR, Montasser ME, Schupf N, Arbeev K, Yashin A, Schork N, Christensen K, Andersen SL, Ferrucci L, Rappaport N, Perls TT, Patti GJ.
Cell Rep. 2024 Nov;43(11):114913.
FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species
Song J, Li Z, Zhou L, Chen X, Sew WQG, Herranz H, Ye Z, Olsen JV, Li Y, Nygaard M, Christensen K, Tong X, Bohr VA, Rasmussen LJ, Dai F.
Nat Commun. 2024 Aug;15(1):7144.
Genome-Wide Epistatic Network Analyses of Semantic Fluency in Older Adults
Tan Q, Li W, Nygaard M, An P, Feitosa M, Wojczynski MK, Zmuda J, Arbeev K, Ukraintseva S, Yashin A, Christensen K, Mengel-From J.
Int J Mol Sci. 2024 May;25(10):5257.
International norms for adult handgrip strength: A systematic review of data on 2.4 million adults aged 20 to 100+ years from 69 countries and regions
Tomkinson GR, Lang JJ, Rubín L, McGrath R, Gower B, Boyle T, Klug MG, Mayhew AJ, Blake HT, Ortega FB, Cadenas-Sanchez C, Magnussen CG, Fraser BJ, Kidokoro T, Liu Y, Christensen K, Leong DP; iGRIPS (international handGRIP Strength) Group.
J Sport Health Sci. 2024 Dec:14:101014.
All-Cause Mortality and Cause-Specific Death in U.S. Long-Lived Siblings: Data From the Long Life Family Study
Yao S, Boudreau RM, Galvin A, Murabito JM, Honig LS, Perls TT, Christensen K, Newman AB.
J Gerontol A Biol Sci Med Sci. 2024 Nov;79(11).