Forskningsprojekter

Effect of glycogen localisation and muscle morphology on muscle function  (Joachim Nielsen, Niels Ørtenblad) Projects includes immobilisation, Soccer, Cross country skiing, aging, type 2 diabetes. Collaborators: Martin Mogensen, Peter Krustrup , Bengt Saltin, HC Holmberg (Sweden), Henriette Pilegaard, Henrik D Schröder , Per Aagaard, Charlotte Suetta, Lars Grøndahl Hvid.

 

Role of  lactate ion on force, muscle excitability and chloride conductance (Niels Ørtenblad) Lactate ion effects on muscle excitability, measured in whole muscle and skinned fibres. Collaborators: Ole Bækgaard Nielsen and Frank de Paoli,, dept. of Physiology, AU.

 

Energy conservation attenuates the loss of skeletal muscle excitability (Niels Ørtenblad) Energy turn-over, Na,K-pump and muscle excitability. Collaborators: Ole Bækgaard Nielsen, dept. of Physiology, AU, Will Macdonald, Perth. 

 

Physiological effects of muscle disuse in young and old individuals (Per Aagaard, Niels Ørtenblad, Ulrik Frandsen, Lars Hvid) Changes in neuromuscular function, muscle morphology, satellite cell activation, and cellullar signaling/apoptosis induced by immobilization and subsequent retraining in young and old individuals. Collaborators: Charlotte Suetta, Abigail MacKay, Centre for Healthy Aging, University of Copenhagen; Irina Conboy, Michael Conboy, University of California at Berkeley; Henrik Schrøder, OUH. 

 

Low-resistance strength training with partial blood-flow occlusion (RBF exercise) (Per Aagaard, Ulrik Frandsen) Cellular NOS signaling and VGF factors in muscle hypertrophy: effects on muscle mechanical performance, muscle fiber size and satellite cell activation in young subjects, aging individuals and sarcopenic patients. Collaborators: Charlotte Suetta, Centre for Healthy Aging, University of Copenhagen; Henrik Schrøder, OUH. 

 

Voltage dependence of Na+ channel and DHPR inactivation (Niels Ørtenblad) Collaborators: Graham Lamb and George Stephenson, la Trobe University, AU. 

 

Causes of excitation-induced muscle cell damage in isometric contractions: mechanical stress or calcium overload? (Niels Ørtenblad) Collaborators: Klavs Madsen. 

 

Neuromuscular function in female athletes at high risk of ACL injury (Mette Zebis, Per Aagaard) Effects of neuromotoric training on risk factors for ACL injury in female elite soccer and team handball players. Collaborators: Jesper Bencke; Hvidovre University Hospital, Copenhagen. 

 

Effects of lifelong training in the elderly (Per Aagaard) Physical capacity, muscle mechanical function and postural balance in elderly exposed to lifelong exercise and training (soccer, gymnastics). Collaborators: Peter Krustrup, Institut for Idræt, Københavns Universitet. 

 

Project with Norwegian elite cross country skiers, arm vs leg exercise (Niels Ørtenblad, Joachim Nielsen) Protein expression, glycogen localisation, SR function, enzyme activity, fibre type distribution, mitochondrial density etc. Collaborators: Bengt Saltin, HC Holmberg (Sweden), Henriette Pilegaard, Karin Söderlund (Sweden), Henrik D Schröder, Ulrik Frandsen. 

 

Short-term strength training (Thomas Madsen, Niels Ørtenblad, Per Aagaard) SR function, fibre type distribution and muscle function Collaborators: Charlotte Suetta, Søren Smedegaard.

 

The quest for speed, characterisation of super fast muscles (Niels Ørtenblad, Ulrik Frandsen, Joachim Nielsen) Muscle morphology and Ca2+ regulation in FT, ST and super fast muscles Collaborators: Coen Elemans (Biologisk Institut, SDU).

 

Protein isoform expression in muscle (Niels Ørtenblad) Expression of Ca2+ regulating protein isoforms in isolated FT and ST fibres, and human muscles from higly trained, controls and old subjects. Collaborators: Satu Manttari, Oulu.

 

Changes in muscle mechanical function with short-term immobilization (Per Aagaard, Jonas Thorlund) Effects of short-term muscle disuse in military Special Forces missions. Collaborators: Peter P. Kristensen Jægerkorpset, Charlotte Suetta, a, Centre for Healthy Aging, University of Copenhagen.

 

Physiological effects of recreational soccer training in young and old men and women (Per Aagaard) Recreational soccer training vs running and strength training: Adaptive changes in mechanical muscle function, cardiovascular capacity and health, bone mineral composition and postural balance. Collaborators: Peter Krustrup, Institut for Idræt, Københavns Universitet, Charlotte Suetta, Centre for Healthy Aging, University of Copenhagen.

 

Muscle fatigue in elite handball, soccer and marathon running (Per Aagaard, Jonas Thorlund) Acute impairments in neuromuscular and muscle mechanical function during and following top-level competition Collaborators: Klavs Madsen, Institut for Idræt, Århus Universitet.

 

Muscle mechanical function in elite handball vs elite soccer (Per Aagaard, Jonas Thorlund) Neuromuscular capacity and maximal muscle strength characteristics (RFD, power, MVC) in elite soccer plaeys vs team handball players Collaborators: Klavs Madsen, Lars Michalsik, Institut for Idræt, Århus Universitet.

 

Trigger point stimulation in Trapezius muscle pain (Per Aagaard) Assessment and evaluation of neuromuscular and mechanical muscle function, effects of trigger point manipulation and training intervention Collaborators: Jan Hartvigsen, Corrie Myburg, IOB, SDU, Anders Holsgaard-Larsen, OUH, SDU.

 

Changes in postural balance with aging and training (Per Aagaard, Paolo Caserotti) Determinants of balance, variability analysis, influence of muscle strength and power, intervention in fallers Collaborators: Ålborg hospital faldklinik.

 

Effects of aging and training on stair walking performance (Per Aagaard) Muscle mechanical function and neuromuscular activity during stair walking in old vs young subjects, effects of training intervention Collaborators: Anders Holsgaard-Larsen, OUH, SDU.

 

Effects of meniscus injury on muscle mechanical and neuromuscular function (Jonas Thorlund, Per Aagaard) Prestages to arthrosis, influence on functional gait capacity, neuromuscular function and mechanical muscle output Collaborators: Ewa Roos, FOF, SDU.

 

Overuse stress fractures in elite rowers (Per Aagaard) Biomechanical and neuromuscular aspects of rib stress fractures in elite rowers, preventive aspects related to ergometer rowing in slides Collaborators: Anders Vinther, Inge-Lis Kanstrup, Herlev Hospital; Tine Alkjær, Panum Institute, Københavns Universitet.

 

Activation and development of myogenic stem cells (satellite cells) (Ulrik Frandsen, Per Aagaard) Effects of aging, immobilization and retraining, Notch signaling, isolated cell culture techniques Collaborators: Charlotte Suetta, Michael Kjær, Centre for Healthy Aging, University of Copenhagen, Irina Conboy, Michael Conboy, University of California at Berkeley; Henrik Schrøder, OUH.

 

Short-term and long-term recovery of gait and mechanical muscle function in elective hip replacement patients (Per Aagaard, Carsten Jensen) Muscle mechanical function and postural balance pre and 12-months post surgery, biomechanical gait analysis, influence of prosthesis type, recovery of maximal leg muscle strength Collaborators: Søren Overgaard, OUH, SDU.

 

Biomechanical aspects of in-vivo tendon function (Per Aagaard) Effects of aging, immobilization, eccentric rehabilitation, collagen cross-linking, training, corticosteroid administration Collaborators:  Peter Magnusson, Mads Kongsgaard, Philip Hansen, Institute of Sports Medicine Copenhagen, Tod Trappe, Ball State University.

 

The adaptive plasticity in muscle architecture and muscle mechanical function with eccentric resistance exercise (Per Aagaard) Effects of eccentric muscle training and muscle-tendon stretching on muscle mechanical function, architectural properties and neuromuscular function Collaborators: Anthony Blazevich, Woolagong University, Australia.

 

Molecular biomechanics of human muscle tendons (Per Aagaard) Biomechanical properties of single human collagen molecules, atomic force microscopy analysis, effects of training intervention Collaborators: Peter Magnusson, Philip Hansen, Institute of Sports Medicine Copenhagen.

 

The optimal stimulus for muscle growth (Per Aagaard) Hypertrophy responses with high force vs low force exercise in human muscle, Neuromuscular aspects, effects on muscle mass and muscle mechanical function Collaborators: Lars Holm, Michael Kjær, Institute of Sports Medicine Copenhagen.

 

Effects of plyometric training on muscle mass and power (Per Aagaard) Effects of plyometric training vs resistance training, mechanical muscle function, stretch-shortening cycle muscle function Collaborators: Kristian Vissing, Henrik Sørensen, Institut for Idræt, Århus Universitet.