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Muscha Steckelings


Telefon: +4565503718

Research interest
The major research interest of Muscha Steckelings’ group is the angiotensin AT2-receptor, which – in contrast to the AT1-receptor – mediates tissue protective actions. Since the spectrum of protective effects of this receptor is broad (e.g. vasodilation, anti-inflammation, anti-fibrosis, anti-apoptosis, neuroregeneration), the AT2-receptor can be regarded as a potential drug target for the treatment of various diseases.

Research in the Steckelings group addresses many aspects of AT2-receptor physiology and pharmacology ranging from AT2-receptor signaling and interaction with other receptors (primarily the receptor MAS) over in vivo models for testing therapeutic efficacy of AT2-receptor stimulation (e.g. in models of diabetic or hypertensive end-organ damage, CNS diseases, fibrotic diseases, chronic inflammatory diseases, cardiovascular diseases, dermatological diseases) to the preclinical and clinical development of AT2-receptor agonists for potential future clinical use.

Methods and Techniques
Cell culture, mRNA and protein analysis, in vitro nitric oxide measurement, Immunoblotting, Immunolocalization, and Immunflorescence microscopy, ELISA techniques, Knock-out animal models.

PhD student: Antonio Augusto Bastos Peluso

Pharmacology and physiology for medical, biomedical and pharmacy students.

USA:   Prof. Colin Sumners, Prof. Michael Katovich, University of Florida, Gainesville

Prof. Tahir Hussain, University of Houston

Sweden:      Prof. Anders Hallberg, Prof. Mats Larhed, Uppsala University

 Assoc. Prof. Lena Lindblad & Prof. Björn Dahlöf, University of Gothenburg

Australia:     Prof. Robert Widdop, Prof. Kate Denton, Dr. Lucinda Hilliard, Monash University

 Prof. Karin Jandeleit-Dahm, Prof. Terri Allen, Baker IDI Heart and Diabetes Institute, Melbourne

Brazil:          Prof. Robson Santos, Federal University of Minas Gerais, Belo Horizonte

Assis. Prof. Daniel Villela, University of Diamantina

Austria:        Dr. Marko Poglitsch, Attoquant

Germany:     Prof. Michael Bader, Max-Delbrück Center for Molecular Medicine

Prof. Jonel Trebicka, University Clinics Bonn

Prof. Reinhard Voll and Dr. Bettina Sehnert, University of Freiburg

Dr. Metin Artuc, Charité – Medical Faculty Berlin

 Dr. Mario Menk, Charité – Medical Faculty Berlin

Netherlands: Prof. Thomas Unger, Maastricht University

Italy:            Dr. Giovanna Castoldi & Prof. Andrea Stella, Università degli Studi di Milano-Bicocca

Prof. Carmine Savoia, Sapienza University of Rome

Slovakia:      Prof. Ludovit Paulis, University of Bratislava

Japan:          Prof. Masatsugu Horiuchi, Ehime University

Membership in Societies

European Council for Cardiovascular Research (Past-President, Advisory Board)

American Heart Association

International Society of Hypertension (Committee on Women in Hypertension)

European Society of Hypertension

Danish Heart Foundation

Working group on Dermato-endocrinology

Selected publications   

84 peer-reviewed publications; 44 publications 2010 - 2015

1 book (editor); 13 book chapters