Fækal mikrobiotatransplantation (FMT)

Klinisk Immunologisk Afdeling, OUH fremstiller og distribuerer fækal mikrobiotatransplantationsprodukter til kliniske afdelinger på samtlige hospitaler i Region Syddanmark. Disse produkter benyttes på daglig basis til rutinebehandling af patienter med tilbagevendende Clostridioides difficile -infektioner (CDI). Forskning indenfor FMT omfatter vurdering og optimering af dens kliniske anvendelse hos patienter med CDI samt undersøgelse af dens kliniske værdi i forbindelse med andre tilstande, med fokus på immundrevne sygdomme som bl.a. gigt og inflammatoriske tarmsygdomme. Vi samarbejder med kliniske afdelinger i Region Syddanmark og med både lokale, nationale og internationale laboratorier, for at evaluere indholdet af FMT-produktet og FMT’s virkningsmekanisme ved hjælp af både immunologiske analyser, kulturomiske metoder, metagenomik og metabolomik.

Medlemmer af forskningsgruppen

Maja Skov Kragsnæs, læge, ph.d.

Dorte Kinggaard Holm, cand.scient., ph.d.

Anne Christine Nilsson, læge

Jens Kjeldsen, læge, ph.d.

Torkell Ellingsen, læge, ph.d.

Ulrik Stenz Justesen, læge, dr.med.

Katrine Agerbo Hovmand, medicinstuderende

Frederik Cold, læge, ph.d.

Emil Ainsworth Jochumsen, læge

Kristina Fruerlund Rasmussen, læge

Samarbejdspartnere fra kliniske afdelinger

Igangværende projekter

FRONT trial – a 52-week superiority RCT evaluating safety and efficacy of multiple capsule FMTs in immune-mediated arthritis and inflammatory bowel disease. Principal investigators: Maja Skov Kragsnæs and Torkell Ellingsen.

FLORA trial – exploration of clinical predictors and effect-modifiers of FMT in patients with moderate to severe psoriatic arthritis. Principal investigators: Maja Skov Kragsnæs and Torkell Ellingsen.

FMT-AUD – a 12-week superiority RCT evaluating safety and efficacy of one FMT in patients with uncomplicated diverticulitis. Principal investigators: Camilla Thorndahl Nielsen and Thomas Bjørsum-Meyer.

FMT culturomics – Impact of storage conditions on live bacteria in faecal microbiota transplantation products using culturomics. Principal investigators: Katrine Agerbo Hovmand, Ulrik Stenz Justesen, and Maja Skov Kragsnæs.

Projektmuligheder for studerende
Studerende er velkomne til at kontakte Maja Skov Kragsnaes (maja.skov.kragsnaes@rsyd.dk), Torkell Ellingsen (torkell.ellingsen@rsyd.dk), eller Dorte Kinggaard Holm (dorte.holm@rsyd.dk) for yderligere information vedr. muligheder for prægraduate projekter.

Oversigt over publikationer

Safety and efficacy of faecal microbiota transplantation in patients with acute uncomplicated diverticulitis: study protocol for a randomised placebo-controlled trial. Thorndal C, Kragsnaes MS, Nilsson AC, et al.  Therapeutic Advances in Gastroenterology 2025;18.

Does This Fecal Microbiota Transplant Work? Quality assurance of capsule based Fecal Microbiota Transplant production. Jochumsen EA, Kragsnaes MS, Nilsson AC, et al.  Scandinavian Journal of Gastroenterology Oct 1, 2024.

Dynamics of inflammation-associated plasma proteins following faecal microbiota transplantation in patients with psoriatic arthritis and healthy controls: exploratory findings from the FLORA trial. Kragsnaes MS, Jensen JRB, Nilsson AC, et al. RMD Open2024;10:e003750.  

Small intestinal permeability and metabolomic profiles in feces and plasma associate with clinical response in patients with active psoriatic arthritis participating in a fecal microbiota transplantation trial: exploratory findings from the FLORA trial. Kragsnaes MS, Blanco JM, Mullish BH, et al.  ACR Open Rheumatol. 2023;10.1002

Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial. Kragsnaes MS, Kjeldsen J, HornHC, et al. Ann Rheum Dis. 20212021 Sep;80(9):1158-1167.

Experiences and perceptions of patients with psoriatic arthritis participating in a trial of faecal microbiota transplantation: a nested qualitative study. Kragsnaes MS, Sødergren ST, Kjeldsen J, et al.  BMJ Open. 2021;11(3):e039471 . 

How do I Establish a Stool Bank for Fecal Microbiota Transplantation within the Blood- and Tissue Transplant Service? Kragsnaes MS, Nilsson AC, Kjeldsen J, et al. Transfusion 2020;60:1135-41. 

Efficacy and safety of faecal microbiota transplantation in patients with psoriatic arthritis: protocol for a 6-month, double-blind, randomised placebo-controlled trial. Kragsnaes MS, Kjeldsen J, Horn HC, et al. . BMJ Open. 2018;8:e019231.