Faecal microbiota transplantation

The Clinical Immunology Research Unit

Faecal microbiota transplantation (FMT)

Faecal microbiota transplantation products are manufactured at the Dept. of Clinical Immunology, OUH, and distributed to clinical departments at all hospitals in the Region of Southern Denmark. These products are used on a daily basis in the routine treatment of patients with recurrent Clostridioides difficile infections (CDI). The research on FMT includes the assessment and optimization of its clinical application in patients with CDI and the investigation into its clinical value in other conditions with a focus on immune-mediated diseases including arthritis and inflammatory bowel disease. We collaborate with clinical departments in the Region of Southern Denmark and with both local, national and international laboratories to evaluate the content of the FMT product and the mode-of-action of FMT using both immunological assays, culturomics, metagenomics, and metabolomics.

Members of the team

Maja Skov Kragsnæs, MD, Ph.D.

Dorte Kinggaard Holm, MSc, Ph.D.

Anne Christine Nilsson, MD

Jens Kjeldsen, MD, Ph.D .

Torkell Ellingsen, MD, Ph.D.

Ulrik Stenz Justesen, MD, DMSc.

Katrine Agerbo Hovmand, medical student

Frederik Cold, MD, Ph.D.

Emil Ainsworth Jochumsen, MD

Kristina Fruerlund Rasmussen, MD

Collaborators from clinical departments

Ongoing projects

FRONT trial – a 52-week superiority RCT evaluating safety and efficacy of multiple capsule FMTs in immune-mediated arthritis and inflammatory bowel disease. Principal investigators: Maja Skov Kragsnæs and Torkell Ellingsen.

FLORA trial – exploration of clinical predictors and effect-modifiers of FMT in patients with moderate to severe psoriatic arthritis. Principal investigators: Maja Skov Kragsnæs and Torkell Ellingsen.

FMT-AUD – a 12-week superiority RCT evaluating safety and efficacy of one FMT in patients with uncomplicated diverticulitis. Principal investigators: Camilla Thorndahl Nielsen and Thomas Bjørsum-Meyer.

FMT culturomics – Impact of storage conditions on live bacteria in faecal microbiota transplantation products using culturomics. Principal investigators: Katrine Agerbo Hovmand, Ulrik Stenz Justesen, and Maja Skov Kragsnæs.

Project options for students

Students are very welcome to contact Maja Skov Kragsnaes (maja.skov.kragsnaes@rsyd.dk), Torkell Ellingsen (torkell.ellingsen@rsyd.dk), or Dorte Kinggaard Holm (dorte.holm@rsyd.dk) for more information on pre-graduate project options.