News

We mapped the proteomic response to diet-induced weight loss in mice across 15 organs/tissues and found that recovery is remarkably asynchronous.

Vikas Shukla joins the Mandrup Group

Lukas Mc.Kenzie Oussoren has obtained his PhD degree

We show that activation of the PPARG locus during human adipocyte differentiation is controlled by a highly interconnected enhancer network.

Using a combination of single-nucleus RNA-seq, bulk RNA-seq and 3D histology, we show how abdominal subcutaneous adipose tissue in men and women with severe obesity adapts to modest lifestyle-induced weight loss followed by substantial bariatric surgery-induced weight loss.

Vallari Shukla and Susanne Mandrup have received a Nordisk Foundation Challenge grant to study cohesin dynamics and its crosstalk with adipogenic transcription factors during regulation of adipogenic lineage determination and adipocyte maintenance.

Susanne Mandrup, Morgane A. Philippe, and Marleen B. Dommerholt have received a grant from the EFSD and Lilly European Diabetes Research Programme for their project “Profiling enhancer activity to uncover transcriptional regulation in isolated human adipocytes”.

Research Assistant Oliver Bonde van Zwol has received a PhD Scholarship from the Danish Diabetes and Endocrine Academy. In his PhD project Oliver will study the transcriptional regulation of leptin expression in human adipocytes.

Our Roadmap is Out: A Step Toward a Unified Single-Cell Atlas of Human Adipose Tissue

Anna Cetnarowska has obtained her PhD degree

Ellen Gammelmark Klinggaard has obtained her PhD Degree

Professor Susanne Mandrup receives the prestigious 'Villum Kann Rasmussen Annual Award' for her lifelong efforts in science

Junior Group Leader, Anne Loft, has received a prestigious 10 million DKK fellowship from the Lundbeck Foundation, to study how a dysfunctional fat tissue in obese individuals contributes to the development of severe liver inflammation and fibrosis.

We review the plasticity and heterogeneity of white adipocytes in response to nutritional overload.

We review how single-cell and single-nucleus transcriptomics have reshaped our understanding of adipose tissue plasticity.

We show that lipolysis is a key mediator of β-adrenergic signaling in brown adipocytes, driving the activation of multiple transcriptional programs.

We review how lineage determination is governed by interactions between transcription factors, coregulators, and chromatin structure.

Prof. Susanne Mandrup and Assist. Prof. Søren Fisker Schmidt were awarded 5.6 million DKK from the health insurance Sygeforsikringen "danmark", for the project "Single cell dissection of healthy and unhealthy adipose tissue in human obesity".

We present a protocol integrating chromatin accessibility and transcriptomic data through IMAGE to identify causal transcription factors driving adipocyte gene programs.

Susanne Mandrup has received DKK 2.999.850 from the Novo Nordisk Foundation for the project “Deciphering the role of enhancer communities and chromatin topology in adipogenic lineage determination”.

We present an optimized protocol for isolating nuclei from mouse adipose tissue to enable single-nucleus RNA sequencing of lipid-filled adipocytes.

In this new review Asst. Prof. Alexander Rauch and Professor Susanne Mandrup review recent advances in the understanding of the transcriptional networks driving stromal cell lineage determination and differentiation.

Using single-nucleus RNA-seq, we show in a collaborative study with the Madsen Group that diet-induced obesity in male mice leads to major transcriptional changes in all cell types in epididymal adipose tissue. We find that in vivo adipocyte differentiation is affected by obesity and demonstrate the existence of three adipocyte subpopulations, one of which is lost in obesity.

Using enhancer capture Hi-C during the differentiation of human MSCs, Madsen et al. show that highly connected enhancers communities act as key drivers of lineage-specific gene programs.

ENHPATHY is a multidisciplinary science consortium created in the frame of the Marie Sklodowska-Curie actions (MSCA)-ITN-ETN European Training Networks call and regrouping 15 academic and 9 non-academic European organisations in the continuum of basic, translational and clinical research on enhancers and associated diseases. Head of unit, Professor Susanne Mandrup is a part of the multidisciplinary consortium.

Great news for two of Prof. Susanne Mandrups Master students. Altogether they received 63.550,- DKK from the Fuhrmann Foundation to support their project: Ellen Gammelmark: “Studying Obesity-Induced Changes in Gene Expression in Mature Adipocytes within Their Tissue Context” and Kaja Madsen: “Investigation of the PPARG2 enhancer network in mesenchymal stem cell differentiation by pairwise enhancer deletion”.