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August 21, 2026
Publication in Nature Metabolism
We mapped the proteomic response to diet-induced weight loss in mice across 15 organs/tissues and found that recovery is remarkably asynchronous.
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August 15, 2026
New postdoc
Vikas Shukla joins the Mandrup Group
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March 20, 2026
PhD degree
Lukas Mc.Kenzie Oussoren has obtained his PhD degree
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March 15, 2026
Publication in Nature Communications
We show that activation of the PPARG locus during human adipocyte differentiation is controlled by a highly interconnected enhancer network.
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January 8, 2026
Publication in Nature Metabolism
Using a combination of single-nucleus RNA-seq, bulk RNA-seq and 3D histology, we show how abdominal subcutaneous adipose tissue in men and women with severe obesity adapts to modest lifestyle-induced weight loss followed by substantial bariatric surgery-induced weight loss.
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December 18, 2025
Novo Nordisk Foundation Grant
Vallari Shukla and Susanne Mandrup have received a Nordisk Foundation Challenge grant to study cohesin dynamics and its crosstalk with adipogenic transcription factors during regulation of adipogenic lineage determination and adipocyte maintenance.
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December 10, 2025
Grant from the EFSD and Lilly European Diabetes Research Programme
Susanne Mandrup, Morgane A. Philippe, and Marleen B. Dommerholt have received a grant from the EFSD and Lilly European Diabetes Research Programme for their project “Profiling enhancer activity to uncover transcriptional regulation in isolated human adipocytes”.
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December 4, 2025
DDEA Co-financed PhD Scholarship
Research Assistant Oliver Bonde van Zwol has received a PhD Scholarship from the Danish Diabetes and Endocrine Academy. In his PhD project Oliver will study the transcriptional regulation of leptin expression in human adipocytes.
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May 15, 2025
Nature Metabolism Review
Our Roadmap is Out: A Step Toward a Unified Single-Cell Atlas of Human Adipose Tissue
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September 18, 2024
PhD degree
Anna Cetnarowska has obtained her PhD degree
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September 13, 2024
PhD degree
Ellen Gammelmark Klinggaard has obtained her PhD Degree
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January 23, 2024
Villum Kann Rasmussen Annual Award
Professor Susanne Mandrup receives the prestigious 'Villum Kann Rasmussen Annual Award' for her lifelong efforts in science
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July 4, 2023
Grant from Lundbeck Foundation
Junior Group Leader, Anne Loft, has received a prestigious 10 million DKK fellowship from the Lundbeck Foundation, to study how a dysfunctional fat tissue in obese individuals contributes to the development of severe liver inflammation and fibrosis.
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June 16, 2023
Current Opinion in Genetics & Development review by Markussen and Mandrup
We review the plasticity and heterogeneity of white adipocytes in response to nutritional overload.
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March 7, 2023
Cell Metabolism review by Maniyadath and Zhang et al.
We review how single-cell and single-nucleus transcriptomics have reshaped our understanding of adipose tissue plasticity.
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July 8, 2022
Publication in Nature Communications
We show that lipolysis is a key mediator of β-adrenergic signaling in brown adipocytes, driving the activation of multiple transcriptional programs.
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June 7, 2022
Trends in Genetics review by Shukla, Cetnarowska, Hyldahl, and Mandrup
We review how lineage determination is governed by interactions between transcription factors, coregulators, and chromatin structure.
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February 17, 2022
Grant from "danmark"
Prof. Susanne Mandrup and Assist. Prof. Søren Fisker Schmidt were awarded 5.6 million DKK from the health insurance Sygeforsikringen "danmark", for the project "Single cell dissection of healthy and unhealthy adipose tissue in human obesity".
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February 15, 2022
Publication in Methods in Molecular Biology
We present a protocol integrating chromatin accessibility and transcriptomic data through IMAGE to identify causal transcription factors driving adipocyte gene programs.
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December 16, 2021
Grant from Novo Nordisk Foundation
Susanne Mandrup has received DKK 2.999.850 from the Novo Nordisk Foundation for the project “Deciphering the role of enhancer communities and chromatin topology in adipogenic lineage determination”.
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September 21, 2021
Publication in STAR Protocols
We present an optimized protocol for isolating nuclei from mouse adipose tissue to enable single-nucleus RNA sequencing of lipid-filled adipocytes.
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April 16, 2021
Nature Review by Rauch & Mandrup
In this new review Asst. Prof. Alexander Rauch and Professor Susanne Mandrup review recent advances in the understanding of the transcriptional networks driving stromal cell lineage determination and differentiation.
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February 25, 2021
Publication in Cell Metabolism
Using single-nucleus RNA-seq, we show in a collaborative study with the Madsen Group that diet-induced obesity in male mice leads to major transcriptional changes in all cell types in epididymal adipose tissue. We find that in vivo adipocyte differentiation is affected by obesity and demonstrate the existence of three adipocyte subpopulations, one of which is lost in obesity.
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October 6, 2020
Publication in Nature Genetics
Using enhancer capture Hi-C during the differentiation of human MSCs, Madsen et al. show that highly connected enhancers communities act as key drivers of lineage-specific gene programs.
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June 3, 2020
MSc student receives PhD Scholarship from DDA
MSc Student Ellen Gammelmark is one of seven students that have received a PhD Scholarship from the Danish Diabetes Academy. In here PhD project Ellen will study adipose tissue plasticity and cellular crosstalk at single-cell resolution during regression of obesity.
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SDU closed 12/3-10/5 2020
Corona virus - SDU closed
SDU follows the recommendations from the danish authorities and is therefore physically closed through May 10 2020. Staff and students are working from home. Please contact us by email or phone.
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February 18, 2020
ENHPATHY - Molecular basis of human enhanceropathies
ENHPATHY is a multidisciplinary science consortium created in the frame of the Marie Sklodowska-Curie actions (MSCA)-ITN-ETN European Training Networks call and regrouping 15 academic and 9 non-academic European organisations in the continuum of basic, translational and clinical research on enhancers and associated diseases. Head of unit, Professor Susanne Mandrup is a part of the multidisciplinary consortium.
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December, 2019
Novo Scholarship program
Student Lena Larsen has been granted 70.000 DKK from September 2020. The grant will support her project "Changes in Human Adipose Tissue Cellular Composition During Obesity" where she expect to gain novel insight into how obesity affects the function and the interplay between the cell types in human visceral and subcutaneous adipose tissue.
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November, 2019
Fuhrmann Foundation Grant
Great news for two of Prof. Susanne Mandrups Master students. Altogether they received 63.550,- DKK from the Fuhrmann Foundation to support their project: Ellen Gammelmark: “Studying Obesity-Induced Changes in Gene Expression in Mature Adipocytes within Their Tissue Context” and Kaja Madsen: “Investigation of the PPARG2 enhancer network in mesenchymal stem cell differentiation by pairwise enhancer deletion”.
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October 25, 2019
Professor Susanne Mandrup receives Order of Dannebrog
As from 25 October 2019, Professor Susanne Mandrup is Knight of the Order of Dannebrog, issued by Her Majesty Queen Margrethe II of Denmark.
