Gut anaerobic bacteria and association with colorectal cancer?
Principal investigators
Flemming Damgaard Nielsen and Ulrik Stenz Justesen
Collaborators
Thomas Vognbjerg Sydenham (Department of Clinical Microbiology, Odense University Hospital), Mikael Lenz Strube (Department of Biotechnology and Biomedicin, DTU Bioengineering (CeMist Center of Excellence)) and Jakob Møller-Jensen, department of biochemistry and molecular biology, University of Southern Denmark
Project
Pangenome wide association study of whole genome sequencing data from Bacteroides spp. from patients with and without colorectal cancer to discover biomarkers specific for colorectal cancer.
Status
Ongoing'
Supported by
The Harboe Foundation, the Region of Southern Denmark, the Hartmann Foundation, Tornøes and Høyrups Foundation, the Novo Nordisk Foundation and the Louis-Hansen Foundation
More information
Flemming.Damgaard.Nielsen@rsyd.dk
Anaerobic bacteremia; Clinical presentation, treatment response and outcome
- A Regional and a Nation-wide study, 2010-2023
Principal investigator
Charlotte Nielsen Agergaard and Ulrik Stenz Justesen
Collaborators
Centre for Clinical Epidemiology (Kim Oren Gradel) and the Department of Surgery (Mark Bremholm Ellebæk), Odense University Hospital and all Danish departments of clinical microbiology
Project
Blood stream infection with anaerobic bacteria accounts for up to 10-15% of bacteremia cases. However, both laboratory diagnostics, clinical evaluation and treatment, have been challenging and anaerobic bacteremia remains associated with significant mortality.
In a regional population-based study, we will focus on Bacteroides species, the most common cause of anaerobic bacteremia, and examine the choice of antibiotic therapy in relation to clinical outcome, and mortality rate.
In a nationwide population-based study, we will investigate the epidemiology, and clinical manifestations of bacteremia with anaerobic bacteria. Furthermore, we aim to investigate comorbidities, including cancers related to anaerobic bacteremia.
Status
Start November 2024
Supported by
The NEYE-Foundation https://www.neye.dk/blog/neye-fonden/
PhD scholarship from the Region of Southern Denmark
PhD Scholarship from the Faculty of Health Sciences, University of Southern Denmark
More information
charlotte.agergaard@rsyd.dk
Anaerobic bacteremia; Clinical presentation, treatment response and outcome
- Prospective study of patients with bacteremia with colorectal cancer-associated bacteria using capsule endoscopy
Principal investigator
Charlotte Nielsen Agergaard and Mark Bremholm Ellebæk (Department of Surgery, Odense University Hospital)
Collaborators
Ulrik Stenz Justesen. Centre for Clinical Implementation of Capsule Endoscopy (CICA), OUH Svendborg Sygehus (Thomas Bjørsum-Meyer and Anastasios Koulaouzidis)
Project
In a prospective clinical study, we will examine patients with anaerobic bacteremia using camera capsule endoscopy for the presence of colorectal cancer (CRC), the most frequent and severe medical condition associated with anaerobic bacteremia.
Status
Start November 2024
Supported by
Kræftens Bekæmpelse, Fabrikant Vilhelm Pedersen og Hustrus Legat
PhD scholarship from the Region of Southern Denmark
PhD Scholarship from the Faculty of Health Sciences, University of Southern Denmark
Centre for Clinical Implementation of Capsule Endoscopy (CICA)
More information
charlotte.agergaard@rsyd.dk
Culturomics – identifying the right gut bacteria for the right patients
Principal investigator
Katrine Agerbo Hovmand
Collaborators
Ulrik Stenz Justesen. Torkell Ellingsen and Maja Skov Kragsnaes (Department of Rheumatology, Odense University Hospital), Emil Ainsworth Jochumsen, Dorte Kinggaard Holm and Anna Christine Nilsson (Department of Clinical Immunology, Odense University Hospital) and Jens Kjeldsen (Department of Medical Gastrointestinal Diseases, Odense University Hospital)
Project
Transplantation with faecal microbiota (FMT) is an established treatment modality of C. difficile infection (CDI). However other diseases such as inflammatory diseases, including inflammatory bowel disease and psoriatic arthritis are also potential targets for FMT. Identifying the right composition of bacteria for treatment is investigated in this study with the purpose of creating our own “soup” of bacteria to become independent of faecal donors.
Status
Ongoing
Supported by
Odense University Hospital and the Novo Nordisk Foundation
More information
ulrik.stenz.justesen@rsyd.dk
1. European antimicrobial resistance surveillance of Bacteroides fragilis 2024:
An ESGAI multicentre multinational study (ReSuBacfrag)
2. Metronidazole resistance in European Bacteroides fragilis - a ReSuBacfrag 2024 substudy
Principal investigator
Ulrik Stenz Justesen
Collaborators
+60 departments of clinical microbiology from +25 European countries
Project
Bacteroides fragilis is the most frequent anaerobic bacterium in blood cultures. It is therefore very important to have updated information on antimicrobial susceptibility in this species. Because of the development of a simple and inexpensive EUCAST method for antimicrobial susceptibility testing, it is possible to conduct large international surveillance studies. The study is applying the same methods and criteria as the European Antimicrobial Resistance Surveillance Network (EARS-Net).
A substudy will investigate the molecular mechanisms behind metronidazole resistance.
Status
2022 study has been published
Ongoing follow-up in 2024
Supported by
ESCMID Study Group on Anaerobic Infections and ESCMID Study Group on Antimicrobial Resistance Surveillance
An ESCMID Study Group Research Grant
More information
https://www.escmid.org/research_projects/study_groups/study_groups_a_f/anaerobic_infections
https://www.ecdc.europa.eu/en/about-us/partnerships-and-networks/disease-and-laboratory-networks/ears-net
https://pubmed.ncbi.nlm.nih.gov/38942247/
https://www.escmid.org/science-research/grants-awards/awardees-gallery/
ulrik.stenz.justesen@rsyd.dk