Ole Nørregaard Jensen is a professor in the Protein Research group at the University of Southern Denmark (SDU), Odense. His research has contributed substantially to the development and application of mass spectrometry for protein science and proteomics. His scientific career spans more than two decades and reflects the evolution of biological mass spectrometry from protein identification toward quantitative, modification-specific and proteoform-resolved analysis.
A major focus of Ole N. Jensen's research is the development of mass-spectrometric approaches for protein characterization and post-translational modification (PTM) analysis in cellular signaling networks. His work has addressed phosphorylation, acetylation, methylation and glycosylation, combining tandem mass spectrometry with computational approaches for confident identification and localization of protein modifications.
Recently, his work has moved toward proteoform science and intact-protein mass spectrometry, integrating high-resolution MS, tandem MS and ion mobility with computational analysis. This approach seeks to characterize intact proteins as molecular entities carrying defined combinations of sequence variants and PTMs. His research therefore addresses a central challenge in modern protein science: connecting molecular heterogeneity to biological function.
Jensen has applied mass spectrometry and proteomics technologies to diverse biological systems, including signalling, disease, biomarkers and cellular regulation. A prominent theme is chromatin and histone biology in the context of cancer, where mass spectrometry provides a unique means of resolving combinations of histone modifications and their biological consequences. His research has contributed to understanding the complex modification patterns that regulate chromatin function and cellular states in health and disease.
Professor Jensen playes a major role in developing research capacity in biomedical mass spectrometry at SDU and in Denmark. He is director of the national collaborative research infrastructure initiatives PLATO and INTEGRA. He is president and founding member of the Danish Proteomics Society (DAPSOC), elected member of the Academy for Technical Sciences (ATV) and he is a Knight of the Order of Dannebrog.
Head of research: Professor, PhD Ole Nørregaard Jensen
Researchers and research group: Ole Nørregaard Jensen Lab
Group webpage: Protein Research Group
A complete list of publications by Ole Nørregaard Jensen can be found in PURE and in PubMed.
Part of the Research section of Biomedical Mass Spectrometry at the Department of Biochemistry and Molecular Biology
