Here you can find our research projects financed by other organisations than the Department of Clinical Microbiology, i.e. funding from public and private organisations, funding from OUH's research funds, Danish regions, universities etc.
You can find more information about our current research projects in the list below.
Externally financed research projects
Project manager
Ulrik Stenz Justesen
Collaboration partners on the project
Collaboration with the EUCAST Laboratory for Antimicrobial Susceptibility Testing, Centrallasarettet, Växjö, Sverige (Gunnar Kahlmeter and Erika Matuschek).
Abstract
Antimicrobial susceptibility testing, using disk diffusion, for anaerobic bacteria is being evaluated to develop a EUCAST method.
Project leader
Thomas Emil Andersen,
Collaboration partners on the project
Department of Molecular Medicine (SDU)
Department of Infectious Diseases Q (OUH)
Abstract
In the project we analyze the viral load and virus neutralization capacity in COVID-19 hospitalized patients as well as in citizens. To do so, we have established one of DK’s only SARS-CoV-2 experimental laboratories at the facilities of Winsløwparken, Odense, DK. Here, patient/citizen samples are cultured, and viral load and neutralization capacity estimated based on plaque assays and plaque reduction neutralisation tests. Throughout 2020-2023 we have analyzed more than 600 patient samples and assisted the assessment of whether contagious virus is present in these persons. In 2021-23, our focus has been assessments of the effect of the COVID-19 vaccines on neutralization capacity in vulnerable patient groups such as kidney- and cancer patients. Lastly, we have investigated the protection provided by the vaccines in healthy individuals against emerging SARS-CoV-2 variants.
During 2020-2023 the project has been funded by the Novo Nordisk Foundation, the Region of Southern Denmark, and the Danish Ministry og Higher Education and Science.
https://novonordiskfonden.dk/da/nyheder/7-nye-projekter-faar-del-i-novo-nordisk-fondens-akutte-coronavirus-pulje/
Project leader, Odense University Hospital
Thomas Emil Andersen
Partners
Odense University Hospital, Dept. of Clinical Microbiology
Danish Fundamental Metrology/DTU
Lighnovo ApS (DK)
Standa (LT)
Abstract
In this project, funded by the European Union and The Innovation Fund Denmark, we collaborate with the Danish Fundamental Metrology Institute, the Danish company LightNovo and the Lithuanian company Standa to develop a miniaturized Raman spectrometer for identification of bacterial infections in wounds. Wound infection is a considerable risk factor especially after surgical procedures and in immune-compromized patients. Fast and reliable identification of pathogenic bacteria in wounds is therefore of utmost importance. This project aims to build a handheld Raman instrument that enables immediate detection of infections in wounds, using novel miniaturized Raman technology coupled with machine learning software.
The project is supported by the EU EUREKA - Eurostars Programme and runs from March 2023 to August 2025.
Project leader, Odense University Hospital
Thomas Emil Andersen
Partners
GlyProvac ApS (DK)
Odense University Hospital, Dept. of Clinical Microbiology
Fraunhofer (DE)
Epitopic GmbH (DE)
Abstract
SVEET - Sugar-modified Vaccine Epitopes; Exploration and Translation
In this EU-funded project we collaborate with the SDU-spinoff GlyProVac (DK), Fraunhofer (DE) og Epitopic GmbH (DE) to develop and perform pre-clinical tests of a novel vaccine candidate against recurrent urinary tract infection. Preclinical evaluation is performed in our porcine UTI model.
The project is supported by the EU EUREKA - Eurostars Programme and runs until March 2024.
For more information
https://southdenmark.be/eu-millioner-til-start-up-der-vil-udvikle-en-vaccine-mod-urinvejsinfektion/
https://dagensmedicin.dk/forskere-faar-millioner-til-udvikling-af-vaccine-mod-blaerebetaendelse
Leading researcher, Region of Southern Denmark
Thomas Emil Andersen
Partners
Region of Southern Denmark
University of Southern Denmark
Biomodics (DK)
Verigraft (SE)
University of Birmingham (GB)
BMD Software (PT)
Viesoji Istaiga Vilniaus Universiteto Ligonine Santaros Klinikos (LT)
Klinikum Rechts der Isar der Technischen Universität Munchen (DE)
Servicio Vasco de Salud Osakidetza (ES)
Region Stockholm (SE)
Abstract
TELEGRAFT is a multi-disciplinary project involving 10 international partners from, Germany, Lithuania, Portugal, Spain, Sweden, and Denmark. Launched in late 2022, the project aims to develop a novel tissue- and blood compatible vascular graft for dialysis. Our tasks in this project are to co-develop antibacterial and tissue-integration properties of the graft, and assist the development of an integrated Raman sensor. Read more about the project here.
The project is supported with 4.8M€ by the European Union and runs until Dec. 2027.
For more information
https://www.sdu.dk/en/forskning/telegraft
https://cordis.europa.eu/project/id/101057673Project manager
Ulrik Stenz Justesen and Flemming Damgaard Nielsen (PhD student)
Abstract
2021. A typing scheme, MLST and cgMLST, is being developed for the Bacteroides fragilis group to be able to establish possible associations with resistance and colorectal cancer.The project is supported by the Harboe Fonden and the Region of Southern Denmark
More information:
https://pubmlst.org/organisms/bacteroides-fragilis
Project leader
Thomas Emil Andersen and Ulrik Stenz Justesen
Abstract
This project aims to elucidate the pathogenesis associated with Clostridium difficile intestinal infection. This organism is a major problem at hospitals worldwide, due to its resistance towards many antibiotics. Patients treated with antibiotics often lose their normal intestinal flora, leaving ideal conditions for C. diff. As a consequence, patients may become chronically infected with C. diff., resulting in significant morbidity among these patients. Using the in vitro intestinal infection models developed by the Clinical Biofilm Group, the colonization mechanisms by C. diff. is investigated and novel treatment regimens are developed and tested.
The project is funded by the MICA foundation and the model development by the SDU Research and Innovation Foundation.