Research aim: Our research aims to identify and understand protein biomarkers related to human disease through mass spectrometry-based proteomics.
Discovery proteomics uses advanced mass spectrometry technology to study proteins in biological samples such as tissue biopsies, cell cultures, blood, and other body fluids. Changes in protein levels can help reveal early signs of disease, and our goal is to decipher the role of specific proteins in disease progression.
Our projects range from basic discovery research focused on understanding fundamental disease mechanisms to clinically relevant analytical studies carried out in close collaboration with clinicians.
Specifically, but not exclusively, we focus on the molecular and cellular aspects of complications in arterial wall in diabetes, and the identification biomarkers for cardiovascular diseases such as abdominal aortic aneurysms, acute myocardial infarction, and cardiogenic shock.
Moreover, we aim to advance mass spectrometry-based proteomics towards routine use in clinical laboratories.
Projects
- Blood biomarker discovery for early detection of cardiovascular disease
- Diagnostic protein biomarkers for malignant mesothelioma or asbestos exposure
- Novel methods for subtyping of systemic amyloidosis and measurement of residual disease in myelomatosis patients with amyloidosis
Available infrastructures and competences
The proteomics laboratory at OUH is equipped with world-class mass spectrometers, associated bioanalytical, bioinformatics, and bio-statistical platforms.
Collaborators, postdocs and PhD students
Our group collaborates with clinicians from leading Danish hospitals and a number of researchers and research groups from Denmark and abroad.
PhD students and postdocs:
- 2024 – 2027: Amanda Jessica Campbell, University of Southern Denmark/Odense University Hospital. PhD student.
- 2025-2027 : Nicolai Bjødstrup Palstrøm, University of Southern Denmark/Odense University Hospital. Post-doc.
Funding
- Danish Heart Foundation
- Odense University Hospital Research Foundation
- Janssen Pharmaceuticals
- AP Møller Foundation (A. P. Møller Fonden)
- Innovation Fund Denmark
- Kræftens Bekæmpelse
- Innovationsfonden
- Danish Cardiovascular Academy
Selected publications
- Palstrøm NB, Nielsen KB, Campbell AJ, Soerensen M, Rasmussen LM, Lindholt JS, Beck HC. Affinity-Enriched Plasma Proteomics for Biomarker Discovery in Abdominal Aortic Aneurysms. Proteomes. 2024 Dec 9;12(4):37.
- Campbell AJ, Cakar S, Palstrøm NB, Riber LP, Rasmussen LM, Beck HC. A Carrier-Based Quantitative Proteomics Method Applied to Biomarker Discovery in Pericardial Fluid. Mol Cell Proteomics. 2024 Aug;23(8):100812.
- Assing K, Laursen CB, Campbell AJ, Beck HC, Davidsen JR. Proteome and Dihydrorhodamine Profiling of Bronchoalveolar Lavage in Patients with Chronic Pulmonary Aspergillosis. J Fungi (Basel). 2024 Apr 25;10(5):314.
- Palstrøm NB, Campbell AJ, Lindegaard CA, Cakar S, Matthiesen R, Beck HC. Spectral library search for improved TMTpro labelled peptide assignment in human plasma proteomics. Proteomics. 2024 Mar;24(6):e2300236.