Jonathan R. Brewer is Professor of Bioimaging and Head of the Quantitative Cell Biology and Bioimaging Section at the University of Southern Denmark. He is Scientific Director of the Danish Molecular Biomedical Imaging Center (DaMBIC) and leads TORI-SDU, the SDU node of the national Biomedical Tissue Modeling and Organoid Research Infrastructure. DaMBIC is a Euro-BioImaging node and a Nikon Center of Excellence.
The Brewer Group develops human tissue models and bioimaging approaches to study tissue function, disease and drug delivery. Its principal biological focus is human skin, including barrier function, adaptation, inflammation, melanoma, and cutaneous and transdermal drug delivery.
The research is organised into three connected programmes:
- Human skin biology, disease and drug delivery: Full-thickness skin, air–liquid-interface and melanoma models are used to examine barrier function, mechanical and inflammatory responses, tumour–immune interactions, and how formulations and delivery technologies control drug penetration, distribution and retention in skin.
- Spatial and chemical tissue imaging: MERFISH, quantitative confocal and super-resolution microscopy, Raman microscopy and stimulated Raman scattering (SRS) reveal molecular composition and spatial organisation in tissues. Through nanoRaman, an Innovation Fund Denmark Grand Solutions project, the group helps develop super-resolution Raman imaging for label-free analysis of biological samples.
- Automated human tissue models: Through TORI-SDU, the group develops standardised workflows for culturing, treating and longitudinally monitoring advanced tissue and organoid models, including organ-on-chip systems and image-based quality control, with an initial focus on reproducible skin models.
Projects span experimental cell and tissue biology, advanced microscopy, optical instrumentation and quantitative data analysis, allowing researchers to contribute through laboratory experiments, technology development or analysis of complex imaging and molecular datasets.
Head of research: Professor, PhD Jonathan R. Brewer
Researchers and research group: Jonathan Brewer Lab
Group webpage: DaMBIC
A complete list of publications by Jonathan Brewer can be found here.
Head of the Research section Quantitative Cell Biology and Bioimaging at the Department of Biochemistry and Molecular Biology
