Grøntved - Group
The Grontved seeks to identify mechanisms controlling gene regulatory networks in parenchymal and non-parenchymal cell types in the steatotic, inflamed and fibrotic liver. We use different genetic strategies in rodents to isolate specific cell types in the liver and various genetic and genomics technologies to characterize the functional genomes. Moreover, we use single cell sequencing technology to characterize non-alcoholic steatohepatitis in obese humans which, together with the mechanistic studies in rodents, may provide novel insights to disease mechanisms regulating the development of non-alcoholic steatohepatitis.