Frank Kjeldsen is Professor and group leader in the Protein Research Group. His research integrates fundamental mass spectrometry, peptide chemistry and proteomics technology development to expand how proteins and proteomes can be measured and understood. A major current focus is the chemistry of peptide anions in negative-ion mass spectrometry, including fragmentation mechanisms, ion mobility, machine-learning-based spectral prediction and the development of complementary positive/negative ion proteomics workflows.
The group also develops high-throughput and computational proteomics methods for deeper and faster analysis of complex biological samples, including bacterial proteomes. These approaches are used to investigate biological function and adaptation across different systems and to support applications in biotechnology and related areas.
A longstanding research interest is the proteomic analysis of biological responses to environmental exposures, including nanoparticles, pesticides and heavy metals. Using deep proteome analysis, complemented by metabolomics and bioimaging, the group has investigated processes such as protein oxidation, antioxidant defence and metabolic adaptation. This remains an important application area for future development of the group’s proteomics technologies.
Across these activities, the overall ambition is to combine fundamental understanding of mass spectrometric chemistry with the development of new analytical capabilities that enable deeper mechanistic insight into biological systems.
Head of research: Professor, PhD Frank Kjeldsen
Researchers and research group: Frank Kjeldsen Lab
A complete list of publications by Frank Kjeldsen can be found here.
Part of the Research section of Biomedical Mass Spectrometry at the Department of Biochemistry and Molecular Biology
