My research focuses on understanding how tissues respond to stress, adapt to changing conditions and progress towards disease. I am particularly interested in how ageing and previous exposures influence tissue vulnerability, what determines whether tissues recover or develop persistent dysfunction, and how changes in one organ influence responses in other organs.
I combine advanced quantitative proteomics, including redox and post-translational modification analysis, with human-relevant 3D tissue models and systems-level approaches.
My current research covers two main directions:
- Human liver models, ageing and disease biology: Development of 3D hepatic spheroids, iPSC-derived liver organoids and multicellular fibrosis models to investigate tissue adaptation, ageing-associated vulnerability, disease progression and pharmacological responses.
- Tissue stress and systemic responses: Investigation of molecular responses to environmental and physiological stress across organs, integrating proteomics with other molecular and functional measurements.
Current Research Projects
FibroLiver (Novo Nordisk Foundation ODIN, 2026–2029) – Developing reproducible human liver fibrosis models for mechanistic research and drug testing in collaboration with academic, clinical and industrial partners.
MARKOPOLO (Horizon Europe, 2025–2029) – Investigating organ-specific and systemic molecular responses to environmental exposures, including air pollution and noise.
Industry Collaboration and Education
I work closely with life science companies to translate scientific methods and human tissue models into reproducible and practically useful research systems. My collaborations include joint research programmes, Industrial PhD projects and company-related student projects.
I also lead the academic development of a new MSc in Molecular Life Science at SDU, designed to connect advanced molecular biology with real-world challenges in research, healthcare and the life science industry.
Collaboration
I welcome academic and industrial collaborations in proteomics, human tissue modelling, ageing, stress and disease biology, and translational research.
Head of research: Associate professor, PhD Adelina Rogowska-Wrzesinska
Researchers and research group: Adelina Rogowska-Wrzesinska Lab
Group Webpage: Protein oxidation and Ageing
A complete list of publications by Adelina Rogowska-Wrzesinska can be found here.
Part of the Research section of Biomedical Mass Spectrometry at the Department of Biochemistry and Molecular Biology
