New Research: Tailored Exercise Therapy and Self-Management Program Improve Quality of Life for People with Multimorbidity

A new study from the University of Southern Denmark and Næstved, Slagelse, Ringsted Hospitals reveals that a personalized program combining exercise therapy and self-management can enhance the quality of life for adults living with multiple chronic conditions.

The MOBILIZE project is among the first studies to investigate the effects of combining structured exercise therapy with targeted self-management support across multiple chronic conditions. Published in Nature Medicine on June 30, the findings demonstrate that participants reported improved quality of life after 12 months—and importantly, that engaging in exercise therapy was safe, even for individuals managing several chronic diseases.

- Multimorbidity represents one of the most pressing challenges in modern healthcare, says Professor Søren T. Skou, principal investigator of the MOBILIZE project. 
- Our study addresses a critical gap in care by offering a patient-centered approach that empowers individuals through both movement and knowledge to better manage life with multiple conditions.

228 Participants—An Average of Seven Diagnoses Each

The study enrolled 228 participants, each randomly assigned to either receive the 12-week intervention in addition to their usual care or to continue with usual care alone. On average, participants were living with seven chronic conditions.

The exercise component was tailored to each individual and included balance and strength training, along with an optional segment where participants could choose activities aligned with their personal goals and preferences.

This was complemented by brief educational modules covering topics such as sleep, pain management, and physical activity—designed to enhance patients’ self-management skills and reduce the risk of further health deterioration.

Ready for Clinical Implementation

Supported by the European Union, the MOBILIZE project marks a significant step toward more patient-centered care for patients with multimorbidity. The next phase for the research team is to implement the program in clinical settings, ensuring that this new knowledge translates into real-world benefits for patients.