Translational Hepatology contributes to GALAXY WP3.
The Section of Translational Hepatology (TransHep) was established ultimo 2018 by Prof. Dr. Jonel Trebicka within the Department of Internal Medicine I at the university hospital of the Goethe University Frankfurt (GUF). The research focus of TransHep isto the test experimental therapies in-vivo in rodent models of fibrosis and ACLF and in-vitro in human and rodent hepatic primary cells and cell lines. Therefore, state-of-the-art techniques are used to assess molecular biology, histology, and haemodynamics. Apart from GALAXY, TransHepparticipates in the collaborative research centre TRR 57 “Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease” funded by Deutsche Forschungsgemeinschaft, the challenge grant “MicrobLiver” (grant number NNF15OC0016692) from the Novo Nordisk Foundation and the European Union's Horizon 2020 research and innovation program MICROB-PREDICT (grant number 825694). Within these platforms, there is a huge variety of scientific events. The interaction between disciplines and work groups is very active and mirrored in the publications arising within these platforms. Furthermore, this Section does not only focus on animal models and basic science but has participated in different multi-centre studies (CANONIC, PREDICT, PRECIOSA, APACHE, and ALLADINE), is part of the Europe-wide CLIF-consortium investigating chronic liver failure and the European Union's Horizon 2020 research and innovation program LIVERHOPE (grant number 731875). Many other national (e.g. GRAFT, INCA) and international (EASL-VALDIG, BAVENO-COOPERATION) networks are now in progress and TransHep plays an important role in these on-going networks.