Forskning og ekspertise
Vi understøtter forskning inden for miljømedicin og klinisk farmakologi ved at udvikle og implementere skræddersyede analytiske metoder til komplekse biologiske prøver.
Vi anvender state-of-the-art analysekemiske metoder og har stor ekspertise inden for både targeted og non-targeted analyse af småmolekylære stoffer. Alle metoder er valideret til forskningsbrug og omfatter stringent kvalitetskontrol med certificerede referencematerialer.
Analysekemiske teknikker:
- Væskekromatografi kombineret med Triple Quadrupole massespektrometri (LC-MS/MS)
- Væskekromatografi kombineret med High Resolution massespektrometri (LC-HRMS)
- Gaskromatografi kombineret med Triple Quadrupole massespektrometri (GC-MS/MS)
- Avancerede prøveforberedelsesteknikker: f.eks. Solid Phase Extraction (SPE)
- Direkte måling af kviksølv ved brug af termisk nedbrydning, guldfilter-amalgamering og kold damp atomabsorptionsspektrometri
Eksempler på aktuelle analyser til humanbiologiske prøver :
- Per- og polyfluorerede alkylstoffer (PFAS)
- Polychlorerede biphenyler (PCB’er) og organoklorforbindelser
- Glukokortikoider i hår
- Kviksølv (Hg)
- Diverse lægemidler og lægemiddelmetabolitter
Analytical Chemistry Laboratory
The Analytical Chemistry Laboratory at CPPEM performs specialized chemical analyses of environmental toxicants, pharmaceuticals, and metabolites in human biological materials and in‑vitro samples. Our core expertise is to develop and perform highly sensitive quantitative analysis of small molecules.
Research & Expertise
We support research projects in environmental medicine and clinical pharmacology by developing and perform sensitive, custom-made analytical methods for complex biological matrices. Our work integrates advanced sample preparation, chromatographic separation, and mass‑spectrometric detection.
We utilize state-of-art analytical methods and have a wide expertise in both targeted and untargeted small‑molecule analysis. All methods are validated for research use and include rigorous quality control with certified materials.
Analytical Techniques
- Liquid Chromatography – Triple Quadrupole Mass Spectrometry (LC‑MS/MS)
- Liquid Chromatography – High‑Resolution Mass Spectrometry (LC‑HRMS)
- Gas Chromatography – Triple Quadrupole Mass Spectrometry (GC‑MS/MS)
- Direct Mercury Analyzer with thermal decomposition, gold‑filter amalgamation, and cold vapor atomic absorption
- Advanced sample preparation: Solid Phase Extraction (SPE)
Examples of Current Analytical Methods
- Per- and polyfluorinated alkyl substances (PFAS) in human biological material
- Polychlorinated biphenyls (PCBs) and organochlorines in serum
- Glucocorticoids in hair
- Mercury (Hg) in blood, urine, and hair
- Pharmaceuticals and metabolites in biological samples