In the context of the Center for Adipocyte Signaling (ADIPOSIGN), the Mandrup Group combines experimental and computational systems approaches to obtain unprecedented insights into how adipocytes receive and respond to signals at the level of the transcriptome and epigenome and how these signals differ between depots, sex and metabolic health. We have used mouse models to establish concepts and are currently applying those to human biopsies and isolated adipocytes.

Several lines of evidence indicate that changes of adipocyte function are primary drivers of obesity comorbidities. Our goal is to understand how changes in signaling states of adipocytes during development of obesity contribute to the adaptation of adipocytes as well as the pathophysiological consequences of obesity.

 

 

This project is supported by a grant from The Novo Nordisk Foundation. 

 

People involved

 

Relevant publications 

L. K. Markussen, S. Mandrup (2023) Adipocyte gene expression in obesity - insights gained and challenges ahead. Curr Opin Genet Dev. 16;81:102060. doi: 10.1016/j.gde.2023.102060.

L. K. Markussen, E. A. Rondini, O. S. Johansen, J. G. S. Madsen, E. G. Sustarsic, A-B. Marcher, J. B. Hansen, Z. Gerhart-Hines, J. G. Granneman, S. Mandrup (2022) Lipolysis regulates major transcriptional programs in brown adipocytes. Nat Commun 13, 3956.

L. O. Huang, A. Rauch, E. Mazzaferro, M. Preuss, S. Carobbio, C. S. Bayrak, N. Chami, Z. Wang, U. M. Schick, N. Yang, Y. Itan, A. Vidal-Puig,M. den Hoed, S. Mandrup, T. O. Kilpeläinen, R. J. F. Loos (2021) Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab. 3(2), 228-243.

A. K. Sávári, E. L. Van Hauwaert, L. K. Markussen, E. Gammelmark, A-B. Marcher, M. F. Ebbesen, R. Nielsen, J. R. Brewer, J. G. S. Madsen, S. Mandrup (2021) Plasticity of Edididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution. Cell Metab. 33(2), 437-453.

A.-B. Marcher*, A. Loft*, R. Nielsen, T. Vihervaara, J.G. Madsen, M. Sysi-Aho, K. Ekroos, S. Mandrup (2015) RNA-Seq and Mass-Spectrometry-Based Lipidomics Reveal Extensive Changes of Glycerolipid Pathways in Brown Adipose Tissue in Response to Cold. Cell Reports 13, 2000-2013. (*equal contribution)

A. Loft, I. Forss*, M.S. Siersbæk*, S.F. Schmidt, A.-S. B. Larsen, J.G.S. Madsen, D. Pisani, R. Nielsen, M.M. Aagaard. A. Mathison, M.J. Neville, R. Urrutia, F. Karpe, E.-Z. Amri, S. Mandrup (2015) Browning of human adipocytes requires KLF11 and reprogramming of PPARγ super-enhancers.  Genes & Dev. 29, 7-22. (* equal contribution)