Transcriptional networks in the regulation of differentiation and metabolism
The research in the Mandrup Group focuses on understanding fundamental aspects of transcriptional networks regulating stem cell development and cellular plasticity. We are specifically interested in transcriptional networks regulating:
- Plasticity of the adipose tissue in obesity and regression (Center for Functional Genomics and Tissue Plasticity (ATLAS))
- Adipocyte signaling states and the dependence on metabolic state, depot, gender and genetic variation (Center for Adipocyte Signaling (ADIPOSIGN))
- Lineage determination and differentiation of adipocyte progenitors
- Plasticity of the endocrine pancreas in response to insulin resistance
We employ detailed molecular and physiological studies, and genome-wide next generation sequencing-based approaches to study transcriptional networks in cell culture and murine model systems as well as in human biopsies.