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Novel preformulation tools

In preformulation, information about new drug substances is collected in order to develop the most promising formulations. Typical information gathered in a high-throughput-setup are crystal structure, melting points, solubilities in different solvents, and chemical stability. In this context, we want to address our efforts to the drug transport properties (permeability) of the substances, to be able to assess these in an early phase of development: being able to select the most promising candidates from the vast number of possible drug candidates, and find the most promising formulation strategies for each of them.

We have developed a permeability tool in a microtiterplate format using our novel artificial biomimetic barrier Permeapad®. We transfer the experiments onto a robotic system.

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Key publications

Jacobsen AC, Krupa A, Brandl M, Bauer-Brandl A: High-Throughput Dissolution/Permeation Screening —A 96-Well Two-Compartment Microplate Approach,Pharmaceutics 2019, 11(5), 227.

Berben, P., Bauer-Brandl, A., Brandl, M., Faller, B., Flaten, G.E., Jacobsen, A.-C., Brouwers, J. , Augustijns, P: Drug permeability profiling using cell-free permeation tools: Overview and applications (2018) in press.

Bibi H.A., Holm R., Bauer-Brandl A.: Use of Permeapad® for prediction of buccal absorption: a comparison to in vitro, ex vivo and in vivo method.  (2016) Eur. J. Pharm. Sci, 93,399-404.

H. A.Bibi, M. di Cagno, R. Holm, A.Bauer-Brandl: PermeapadTM for investigation of passive drug permeability: the effect of surfactants, co-solvents and simulated intestinal fluids (FaSSIF and FeSSIF), Int. J. Pharmaceutics (2015),493, 192-197

di Cagno M., Bibi H.A., Bauer-Brandl,A.: New Biomimetic Barrier PermeapadTM for Efficient Investigation of Passive Permeability of Drugs.  (2015) Eur. J. Pharm. Sci., 73, 29-34, DOI10.1016/j.ejps.2015.03.019

Department of Physics, Chemistry and Pharmacy University of Southern Denmark

  • Campusvej 55
  • Odense M - DK-5230
  • Phone: +45 6550 3520

Last Updated 10.08.2023