In a bottom-up process we are able to design nano-particles of different composition including polymers and natural ingredients. Spray drying using physiological phospholipids to make drug-loaded SPLN (solid phospholipid nanoparticles) is one example.
Chitosan nanoparticles have also been made.
Fong, S.Y.K., Ibisogly, A., Bauer-Brandl, A. Solubility enhancement of BCS Class II drug by solid phospholipid dispersions: Spray drying versus freeze-drying. (2015) Int J Pharm, 496 (2), pp. 382-391. DOI: 10.1016/j.ijpharm.2015.10.029
Fong, S.Y.K., Brandl, M., Bauer-Brandl, A.: Phospholipid-based solid drug formulations for oral bioavailability enhancement: A meta-analysis. (2015) Eur J Pharm Sci, 80, pp. 89-110. DOI: 10.1016/j.ejps.2015.08.005
Brinkmann-Trettenes, U., Bauer-Brandl A.: Solid Phospholipid Nano-Particles: Investigations into Formulation and Dissolution Properties of Griseofulvin. (2014) Int. J. Pharmaceutics, 467, 42-47, DOI 10.1016/j.ijpharm.2014.03.023