The NMR group´s focus is on implementing and developing methods to investigate API and model systems. We are interested in quantitative analysis but also in the structure, transport (distribution, diffusion and permeation) and complex formation (diffusion, structure and binding constants) of these materials.
di Cagno, M.C. & Stein, P. C: Studying the effect of solubilizing agents on drug diffusion through the unstirred water layer (UWL) by localized spectroscopy, European Journal of Pharmaceutics and Biopharmaceutics, 2019.
Elvang, P. A., Bohsen, M. S., Stein, P. C., Bauer-Brandl, A., Riethorst, D., Brouwers, J., Augustijns, P. & Brandl, M: Co-existing colloidal phases of human duodenal aspirates: Intraindividual fluctuations and interindividual variability in relation to molecular composition, Journal of Pharmaceutical and Biomedical Analysis 2019, 170, 22-29.
Elvang, P. A., Jacobsen, A. C., Bauer-Brandl, A., Stein, P. C. & Brandl, M., Co-existing colloidal phases in artificial intestinal fluids assessed by AF4/MALLS and DLS: A systematic study into cholate & (lyso-) phospholipid blends, incorporating celecoxib as a model drug, European Journal of Pharmaceutical Sciences. 2018,120, 61-72
Di Cagno, M. P., Clarelli, F., Vabenø, J., Lesley, C., Rahman, S. D., Cauzzo, J., Franceschinis, E., Realdon, N. & Stein, P. C.: Experimental Determination of Drug Diffusion Coefficients in Unstirred Aqueous Environments by Temporally Resolved Concentration Measurements, 2018, Molecular Pharmaceutics. 15, 4, 1488-1494.
P.A. Elvang, P.C. Stein, A. Bauer-Brandl, M. Brandl: Characterization of co-existing colloidal structures in fasted state simulated fluids FaSSIF: A comparative study using AF4/MALLS, DLS and DOSY, J. Pharm. Biomed. Analysis (2017) 145, 531-536, DOI 10.1016/j.jpba.2017.07.014