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A new target against lymphoma

A major focus of our group is to find new targets on cancer cells that can be used in CAR therapy. We have identified BAFF-R, a surface receptor that is overexpressed in mantle-cell lymphoma and on B-cells, and developed new CARs that utilize this antigen. This work has given new insights into the biology of BAFF-R, and how CARs with varying affinity affects T-cell efficacy and the development of cancer escape-variants.

Last Updated 23.02.2024