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CAR NK mediated targeting of CD19 low cancers

Relapse in cancer patients undergoing CAR therapy can occur due to cancer cells downregulating surface antigens. With CARs utilizing CD19 as a target to locate and eliminate cancers, downregulation of CD19 poses a challenge to CAR-mediated therapy.
We are investigating the potential of CAR NK cells to target cancer cells with low amounts of surface CD19 antigen as a method to overcome relapse in patient cases with downregulated surface CD19 antigen.

Last Updated 26.01.2024