Shan Wang, René Hübner, Henrik Karring, Vasco F. Batista, Changzhu Wu

A Supramolecular Approach to Engineering Living Cells with Enzymes for Adaptive and Recyclable Cascade Synthesis

Coating live cells with supramolecular polymers through electrostatic interactions created SupraBAC, a bacteria more resilient to environmental stresses. Host-guest interactions then enabled the ready immobilization of enzymes on SupraBAC for efficient and recyclable multi-enzymatic cascade reactions. This approach both enhances the stability and recyclability of biocatalysts, while also offering a sustainable approach for complex chemical synthesis.