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Molecular Microbiology

Research in the section for Molecular Microbiology is focused on understanding the basic molecular physiology of bacteria, with the goal of contributing to the cure and prevention of infectious disease.

The pathogenic bacteria which are the objects of current research include Escherichia coli (urinary tract infections), Methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pneumoniae (invasive pneumococcal infections) and the foodborne pathogen Listeria monocytogenes. Other research projects are concerned with exotic non-pathogenic bacteria, such as Thermus thermophilus which grows at high temperatures and Caulobacter crescentus, which has a complex life cycle.

In the section for Molecular Microbiology researchers, technical staff and students collaborate in a positive working climate, sharing knowledge and equipment. Our goal is to obtain maximum synergy within the various research areas currently being investigated:

  • Virulence mechanisms and avoidance of immune response
  • Host – pathogen interactions
  • Antibiotic resistance – origins, mechanisms and possibilities for reversal
  • Anti-virulence agents and their mechanisms of action
  • The role of small RNA molecules in control of bacterial growth and adaptation
  • Identification and function of RNA modifications

Research and development in the section for Molecular Microbiology is carried out in collaboration with international academic and industrial partners with the aim of developing novel approaches to  combat infectious disease. A common vision is shared by researchers, technical staff and students to translate knowledge from basic research to clinical applications.

The techniques used by the section for Molecular Microbiology are constantly being updated, and include the following:

  • Classical molecular microbiological techniques such as cloning, mutant construction, strain characterisation and microscopy
  • Assays for antibiotic resistance
  • Mechanisms of pathogenicity
  • Latest-generation sequencing techniques for DNA and RNA
  • Investigations of protein-nucleic acid interactions
  • Flow-cytometry and cell sorting
  • Mass spectrometry and HPLC

Extensive collaboration contributes to the friendly atmosphere characterising the Molecular Microbiology section. Job-satisfaction is increased by the feeling of advancing the boundaries of knowledge and contributing to human welfare by combating infectious disease.

Biochemistry and Molecular Biology

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Department of Biochemistry and Molecular Biology University of Southern Denmark

  • Campusvej 55
  • Odense M - DK-5230
  • Phone: +45 6550 2412

Last Updated 14.02.2024