Spatial Lipidomics and Imaging Mass Spectrometry

We use imaging mass spectrometry to map the spatial organization of metabolites and lipids directly within tissues. This approach allows us to visualize how metabolic pathways are compartmentalized across distinct cell types and anatomical structures in organs such as adipose tissue, liver, skin, and tumors. By integrating spatial lipidomics with traditional LC–MS metabolomics and functional experiments, we investigate how local metabolic environments shape tissue function and disease progression. Our work aims to uncover spatial metabolic heterogeneity that cannot be captured by bulk analyses. Ultimately, these studies provide a spatial dimension to metabolism and help link molecular lipid signatures to tissue physiology and pathology.