Hepatic transcriptional oscillation such as circadian rhythm is tightly coupled to diet composition and temporal feeding pattern. Whereas the diurnal genome-wide changes in hepatic chromatin structure have been studied extensively less is known about dynamic regulation of chromatin organization in response to feeding per se.

We seek to characterize structural changes to chromatin structure in response to acute feeding and relate chromatin remodeling with transcriptional reprogramming. We use integrated transcriptomic and cistromic analysis to identify gene regulatory networks involved in the hepatic feeding response and mouse genetics to perturb these regulatory networks.  

Related publications by the Grøntved group

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in the liver

High fat dietinduced changes of mouse hepatic transription and enhancer activity can be reversed by subsequent weight loss

C57BL6J substrain differences in response to high-fat diet intervention