ADIPOSIGN is a research center established for a six-year period (2019-2025) through a major grant from the Novo Nordisk Foundation. We combine experimental and computational systems approaches to obtain unprecedented insights into how fat cells receive and respond to signals at the level of the (epi)-genome and the cell membrane. Our goal is to understand how the signaling states of adipocytes depend on depot, gender and genetic variation, and how changes in these signaling states during development of obesity contribute to the pathophysiological consequences of obesity.
The center involves the following PIs:
- Susanne Mandrup, Professor, Department of Biochemistry and Molecular Biology, University of Southern Denmark (Director)
- Jan-Wilhelm Kornfeld, Professor, Department of Biochemistry and Molecular Biology, University of Southern Denmark
- M. Madan Babu, Director of the Center Data Driven Discovery, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, US
- Zach Gerhart-Hines, Associate Professor, Center for Basic Metabolic Research, University of Copenhagen
ADIPOSIGN is associated with the Center for Functional Genomics and Tissue Plasticity (ATLAS) recently supported by a center of excellence grant from the Danish National Research Foundation and directed by Susanne Mandrup.