Skin Lipid Metabolism as a Regulator of Systemic Energy Homeostasis

The skin is emerging as an active metabolic organ with the capacity to influence whole-body energy balance. We investigate how lipid synthesis, remodelling, and signalling in the skin contribute to systemic metabolic regulation. By combining spatial mass spectrometry with functional mouse models, we explore how alterations in epidermal lipid metabolism affect barrier functions, adipose tissue function, and insulin sensitivity. This work challenges the traditional view of the skin as merely a barrier organ and positions it as a regulator of systemic energy homeostasis.