Regulation of Systemic Metabolism by Exercise-Induced Metabolites

Physical activity induces a complex network of circulating metabolites that act as signalling molecules between tissues. We study how specific exercise-induced metabolites regulate glucose uptake, mitochondrial function, and systemic energy balance. Combining human cohort studies with mechanistic mouse and cell experiments, we aim to identify bioactive metabolites that mediate the metabolic benefits of exercise. Our  work focuses on metabolite signalling and the downstream signalling pathways they activate in metabolic tissues. By defining these exercise-responsive metabolic signals, we aim to uncover new strategies to mimic or potentiate the beneficial effects of physical activity in cardiometabolic disease.