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About Clinical Genome Center

Our senior researchers are often involved from the very beginning of a project with selecting a strategy and design of analyses that will enable the investigation of a specific research question, and description of these analyses with associated budget costs in funding applications. We share our laboratory facilities with Dept. of Clinical Genetics at OUH and have state of the art equipment for molecular analysis such as high-throughput Illumina sequencing, Oxford Nanopore long range-sequencing and 10X Genomics single-cell RNA sequencing. Subsequent bioinformatic analyses can be performed by our bioinformaticians, who in collaboration with senior researchers will also contribute to the interpretation of data. The staff has long experience in targeted and global germline testing, somatic mutation profiling in cancer, gene expression profiling, and several other types of analyses.  Senior researchers from several other clinical departments are connected to the center and as such users can get qualified input or advice on a broad range of research topics.

Support is provided in close collaboration with:

  • PREmedico which is a more general discussion- and information forum within personalized medicine.
  • OPEN who provides research support for register based research projects and for the creation of databases for clinical projects.
  • SDU e-Science Center, who provides access to high performance computing.
 

The predecessor of the Clinical Genome Center was established back in 2001 after a 10 mill dkr start-up grant from the Danish Research Agency and called the Human MicroArray Center (HuMAC). In 2014 it received a 3.75 mill dkr grant from the OUH Frontline Programme 2014-17 and was renamed to Clinical Genome Center. In 2018 the Center received an 8.7 mill dkr grant from the Region of Southern Denmark for purchase of hardware and a 9.3 mill dkr grant from University of Southern Denmark as part of the SDU Strategic Plan for Personalized Medicine. These grants allowed for a general increase of the Center’s capacity with the purchase of a state of the art sequencer (Illumina NovaSeq 6000) as well as the employment of additional laboratory technical staff, bioinformaticians and a research coordinator. The center is headed by Professor Torben A. Kruse.

The majority of projects in the Center are externally funded and often led by a PI from a clinical department.

 

Last Updated 02.07.2020