Title of the talk:
Apolipoprotein M - a potential regulator of brown fat activity
Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1–5). Lack of apoM increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or β3-adrenergic stimulation). Moreover, studies suggest that that mice with overexpression of human apoM have a significant delayed triglyceride turnover. Finally, novel data suggest that S1P and apoM may play dependent as well as independent biological functions in BAT and triglyceride metabolism. The results reveal a link between the apoM/S1P axis and energy metabolism.
The seminar takes place at BMB Seminar room - V18-501-1 - Building 37, SDU Odense