Group leader: Jelena Ostojic
Department & University/Hospital/Other:
Department of Clinical Research
Research Unit of Radiology
Faculty of Health Sciences
University of Southern Denmark
Jelena.Ostojic@rsyd.dk - www.ouh.dk
Tlf. +45 21811743
Radiologisk Afdeling
Odense Universitetshospital
Kløvervænget 47, Indgang 27 stuen, 5000 Odense C
Description of research:
1.The effect of oral dimethyl-fumarate on MRI outcomes and correlation with changes of neurofilament levels and inflammatory molecules in the CSF
This PhD project was supervised by Profesor Zsolt Illes, the Thesis will be submitted.
We plan to add the MRI as a continuation study.
2.Interactions between progressing pathology and health measurement scales in the domains of the International Classification and Function in progressive Multiple Scle-rosis (a PhD project) it is a prospective 2-years study with patients with high risk for secondary progression and definite secondary progressive MS, biomarker/MRI/health measurement scales outcomes; comparing the 2 groups and correlation between out-comes
Mads Ravnborg PhD project supervised by Professor Zsolt Illes
3. New MR scanning methods for diagnosis of brain cancer without surgery, Professor Frantz Rom Poulsen
Key publications (last 10 years):
Jasmina Boban, Dusko Kozic, Vesna Turkulov, Jelena Ostojic, Robert Semnic, Dajana Lendak, Snezana Brkic. HIV-associated neurodegeneration and neuro-immunity: multivoxel MR spectroscopy study in drug-naive and treated patients. Eur Radiol. DOI 10.1007/s00330-017-4772-5 Published online 14 March 2017
Magnussen LV, Andersen PE, Diaz A, Ostojic J, Højlund K, Hougaard DM, Chris-tensen AN, Nielsen TL, Andersen MS. MR-spectroscopy of hepatic-fat and adi-ponectin and leptin levels during testosterone therapy in type 2 diabetes. A ran-domized, double-blinded, placebo-controlled trial. Eur J Endocrinol. 2017 May 18. EJE-17-0071. doi: 10.1530/EJE-17-0071. [Epub ahead of print]
Sergej M. Ostojic, Jelena Ostojic, Patrik Drid, Milan Vranes. Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men. Applied Physiology, Nutrition, and Metabolism, 2016, 41(9): 1005-1007,10.1139/apnm-2016-0178 Epub 2016 Jun 13 DOI: 10.1139/apnm-2016-0178
Sergej M. Ostojic, Jelena Ostojic, Patrik Drid, Milan Vranes, Pavle Jovanov. Die-tary guanidinoacetic acid increases brain creatine levels in healthy men. Nutrition. Published online: June 8.2016. Article in Press. DOI: http://dx.doi.org/10.1016/j.nut.2016.06.001
Ostojic SM, Drid P, Ostojic J. Guanidinoacetic acid increases skeletal muscle crea-tine stores in healthy men. Nutrition. 2016 Jun;32(6):723-4. doi: 10.1016/j.nut.2015.11.006. Epub 2015 Dec 18.
Jančić J, Dejanović I, Radovanović S, Ostojić J, Kozić D, Đurić-Jovičić M, Sa-mardžić J, Ćetković M, Kostić V. White Matter Changes in Two Leber's Hereditary Optic Neuropathy Pedigrees: 12-Year Follow-Up. Ophthalmologica. 2016;235(1):49-56. doi: 10.1159/000441089. Epub 2015 Nov 6
Ana Potic, Vera Popovic, Jelena Ostojic, Sandra Pekic, Dusko Kozic, Kether Guer-rero, Raphael Schiffmann, Geneviève Bernard. Neurogenic bladder and neuroen-docrine abnormalities in Pol III-related leukodystrophy. BMC Neurol. 2015 Mar 4;15:22. doi: 10.1186/s12883-015-0283-7
Ostojic J, Kozic D, Pavlovic A, Semnic M, Todorovic A, Petrovic K, Covickovic-Sternic N. Hippocampal diffusion tensor imaging microstructural changes in vas-cular dementia. Acta Neurol Belg. 2015 Dec;115(4):557-62. doi: 10.1007/s13760-014-0419-3. Epub 2015 Jan 3.
Potic A, Pavlovic AM, Uziel G, Kozic D, Ostojic J, Rovelli A, Sternic N, Bjelan M, Sarto E, Di Bella D, Taroni F. Adult-onset autosomal dominant leukodystrophy without early autonomic dysfunctions linked to lamin B1 duplication: a phenotyp-ic variant. J Neurol (2013) 260:2124-2129.
D.B. Kozic, R.Semnic, I. Petrovic, M. Svetel, J. Ostojic and V. S .Kostic. Are irre-versible morphological signs of portal hypertension in neurological form of Wil-son’s disease associated with treatment delay? A pilot study. Acta Neurol Belg. 2012 S ep; 112(3):261-4.
Kozic D, Njagulj V, Ostojic J, Sekulic S, Zarkov M. Atypical cerebral venous thrombosis: MRI and MRS features. Arch Neurol. 2012 Jul; 69(7):930-1.
Pavlovic A, Bonaci-Nikolic B, Kozic D, Ostojic J, Abinun M, Svabic-Medjedovic T, Nikolic M, Sternic N. Progressive multifocal leukoencephalopathy associated with mycophenolate mofetil treatment in a woman with lupus and CD4+ T-lymphocyte deficiency. Lupus 2012;21(1):100-2.
Ostojic J, Kozic D, Lucic M, Konstantinovic J, Covickovic-Sternic N, Pavlovic A, Bogdanovic-Stojanovic D, Semnic R. Multivoxel MRS: right frontal parafalcine cortex - area of neurobiochemical gender differentiation? Neuro Endocrinol Lett. 2011;32(5):683-687.
Aleksandar J. Ristić, Jelena Ostojić, Duško Kozić, Nikola M. Vojvodić, Ljubica M. Popović, Slavko Janković, Vladimir Baščarević, Dragoslav V. Sokić. Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy: 3D multivoxel spectroscopy study. Journal of the Neurological Sciences 2011;305:139-142.
D.Kozic, M. Zarkov, R.R. Semnic, J. Ostojic, B. Radovanovic, D. Ivanovski. Over-looked early CT signs of cerebral venous thrombosis with lethal outcome. Acta Neurol. Belg. 2010; 110:345-348.
Nada Vuckovic, Dusko Kozic, Petar Vulekovic, Dejan Vuckovic, Jelena Ostojic, Robert Semnic: MR and MRS Characteristics of Intraventricular Meningioma. J Neuroimaging 2010; 3:294-269.
J.Ostojic, D. Kozic, J. Konstantiovic, N. Covickovic-Sternic, M. Mijajlovic, K. Koprivsek, R. Semnic. Three-dimensional multivoxel spectroscopy of the healthy hippocampus-are the metabolic differences related to the location? Clinical Radi-ology. 2010; 65:302-307.
Jelena Ostojic, Jasna Jancic, Dusko Kozic, Robert Semnic, Katarina Koprivsek, Mladen Prvulovic, Vladimir Kostic. Brain white matter 1 H MRS in Leber optic neuropathy mutation carriers. Acta Neurol. Belg. 2009; 109:305-309.
Key collaborations:
Danish: Professor Zsolt Illes, Professor Frantz Rom Poulsen
International: Professor Sergej Ostojic, Professor Dusko Kozic
Infrastructure:
I have rich experience with implementing, novel MR sequences and image analysis.