Factsheet by Helle Hvilsted Nielsen

Group name: Nielsen
Group leader: Helle Hvilsted Nielsen
Group members:
Katrine Tækker Jensen, PhD student
Laura Davidsen, ITEK student
Minna Lund, PhD student
Department & University/Hospital/Other: Department of Neurology, Odense University Hospital, Institute for Molecular Medicine, University of Southern Denmark
Funding sources: Danish Society for Multiple Sclerosis

Description of research:
1. Clinical and paraclinical research in neuromyelitis optica and multiple sclerosis
2. Pathogenic mechanisms in neuroinflammatory disorders


Key publications (last 10 years):
Gebregiworgis T, Nielsen HH et al. (2016): A Urinary Metabolic Signature for Multiple Sclerosis. J Proteome Res

Waters P, Reindl M, Saiz A, Schanda K, Tuller F, Kral V, Nytrova P, Sobek O, Nielsen HH et al. (2016): Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica. J Neurol Neurosurg Psychiatry.

Nielsen HH et al. (2015): The Urine Proteome Profile is Different in Neuromyelitis Optica Com-pared to Multiple Sclerosis. PlosOne

Grebing MM, Nielsen HH et al (2015): Myelin Specific T Cells Induce Interleukin-1beta Expres-sion in Lesion-Reactive Microglia in Zones of Axonal Degeneration. In press. GLIA

Nielsen HH, et al. (2014): Diagnostik og behandling af Neuromyelitis Optica. Ugeskr Laeger.

Banati M, Csecsei P, Koszegi E, Nielsen HH et al. (2013): Antibody response against gastrointes-tinal antigens in demyelinating diseases of the central nervous system. Eur J Neurol.

Nielsen HH et al. (2012): Treatment of Helicobacter Pylori and risk of developing Parkinson’s dis-ease in Denmark. Eur J Neurol.

Nielsen HH et al. (2011): Stimulation of adult oligodendrogenesis by myelin specific T-cells. Am J Pathol.

Nielsen HH et al. (2009): Enhanced microglia clearance of myelin debris in T-cell infiltrated central nervous system. J Neuropathol Exp Neurol.

Drøjdahl N*, Nielsen HH* et al. (2010): Axonal plasticity elicits long-term changes of oligoden-droglia and myelinated fibres. Glia. (*equal contribution)

Nielsen HH et al. (2006): Axonal Degeneration Stimulates the Formation of NG2+ Cells and Oli-godendrocytes in the Mouse. Glia

Other outputs:
1 filed patent: Fumaric acid derivatives for medical use: SDU ref.: 14/5668; P&V ref.: 54985US01


Key collaborations:
Danish:
Dept of Neurology, OUH: Prof Zsolt Illes, David Gaist
Center for Clinical Proteomics, OUH: Prof Niels Heegaard
Dept of Orhtopedic Surgery, OUH: Ass Prof Lars-Henrik Frich
Dept of Opthalmology: Prof. Jakob Grauslund
Dept. of Reumatology: Consultant Keld-Erik Byg
Institute of Molecular Medicine: Prof Bente Finsen, Ass prof Kate Lambertsen

International:
University of Miami: Ass Prof Roberta Bramilla


Infrastructure:
Patients with inflammatory disorders of the CNS, including clinical database and biobank with couples samples of urine, plasma, sera, CSF, RNA and DNA