Group name: Nielsen
Group leader: Helle Hvilsted Nielsen
Katrine Tækker Jensen, PhD student
Laura Davidsen, ITEK student
Minna Lund, PhD student
Department & University/Hospital/Other: Department of Neurology, Odense University Hospital, Institute for Molecular Medicine, University of Southern Denmark
Funding sources: Danish Society for Multiple Sclerosis
Description of research:
1. Clinical and paraclinical research in neuromyelitis optica and multiple sclerosis
2. Pathogenic mechanisms in neuroinflammatory disorders
Key publications (last 10 years):
Gebregiworgis T, Nielsen HH et al. (2016): A Urinary Metabolic Signature for Multiple Sclerosis. J Proteome Res
Waters P, Reindl M, Saiz A, Schanda K, Tuller F, Kral V, Nytrova P, Sobek O, Nielsen HH et al. (2016): Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica. J Neurol Neurosurg Psychiatry.
Nielsen HH et al. (2015): The Urine Proteome Profile is Different in Neuromyelitis Optica Com-pared to Multiple Sclerosis. PlosOne
Grebing MM, Nielsen HH et al (2015): Myelin Specific T Cells Induce Interleukin-1beta Expres-sion in Lesion-Reactive Microglia in Zones of Axonal Degeneration. In press. GLIA
Nielsen HH, et al. (2014): Diagnostik og behandling af Neuromyelitis Optica. Ugeskr Laeger.
Banati M, Csecsei P, Koszegi E, Nielsen HH et al. (2013): Antibody response against gastrointes-tinal antigens in demyelinating diseases of the central nervous system. Eur J Neurol.
Nielsen HH et al. (2012): Treatment of Helicobacter Pylori and risk of developing Parkinson’s dis-ease in Denmark. Eur J Neurol.
Nielsen HH et al. (2011): Stimulation of adult oligodendrogenesis by myelin specific T-cells. Am J Pathol.
Nielsen HH et al. (2009): Enhanced microglia clearance of myelin debris in T-cell infiltrated central nervous system. J Neuropathol Exp Neurol.
Drøjdahl N*, Nielsen HH* et al. (2010): Axonal plasticity elicits long-term changes of oligoden-droglia and myelinated fibres. Glia. (*equal contribution)
Nielsen HH et al. (2006): Axonal Degeneration Stimulates the Formation of NG2+ Cells and Oli-godendrocytes in the Mouse. Glia
1 filed patent: Fumaric acid derivatives for medical use: SDU ref.: 14/5668; P&V ref.: 54985US01
Dept of Neurology, OUH: Prof Zsolt Illes, David Gaist
Center for Clinical Proteomics, OUH: Prof Niels Heegaard
Dept of Orhtopedic Surgery, OUH: Ass Prof Lars-Henrik Frich
Dept of Opthalmology: Prof. Jakob Grauslund
Dept. of Reumatology: Consultant Keld-Erik Byg
Institute of Molecular Medicine: Prof Bente Finsen, Ass prof Kate Lambertsen
University of Miami: Ass Prof Roberta Bramilla
Patients with inflammatory disorders of the CNS, including clinical database and biobank with couples samples of urine, plasma, sera, CSF, RNA and DNA
Factsheet by Helle Hvilsted Nielsen
Group name: Nielsen