Ring-closing metathesis (RCM) has recently been one of the most powerful tools in synthetic organic chemistry. Thus, applying a catalyst (e.g. one of the following two developed by Grubbs), both small and large unsaturated cyclic rings can easily be obtained.
Posters
Bi- and Tricyclic Nucleoside Derivatives restricted in S-type Conformations and obtained by RCM Reactions [PDF] (Nanna Albæk)
Publications
Freitag, Morten; Thomasen, Helena; Christensen, Nanna K.; Petersen, Michael; Nielsen, Poul. A ring-closing metathesis based synthesis of bicyclic nucleosides locked in S-type conformations by hydroxyl functionalised 3',4'-trans linkages. Tetrahedron, 2004, 60, 3775-3786. [Abstract]
Ravn, Jacob; Freitag, Morten and Nielsen, Poul. Bicyclic nucleosides; stereoselective dihydroxylation and 2'-deoxygenation. Org. Biomol. Chem. 2003, 1, 811-816. [Abstract]
Ravn, Jacob; Nielsen, Poul : Synthesis of bicyclic nucleosides by ring-closing metathesis, J. Chem. Soc., Perkin Trans. 1: 2001; 985-993. [Abstract]
Ravn, Jacob; Thorup, Niels; Nielsen, Poul: A conformationally locked tricyclic nucleoside. Synthesis, crystal structure and incorporation into oligonucleotides, J. Chem. Soc., Perkin Trans. 1: 2001; 1855-1861. [Abstract]