A series of nucleosides with two nucleobases have been approached for nucleic acid targeting and for the preparation of artificial nucleic acid secondary structures.
Publications
Christensen,Mikkel S.; Madsen, Charlotte M. and Nielsen, Poul. Synthesis and modelling of DNA junction and minor groove zipper motifs incorporating the double-headed nucleoside 5 (S)–C-(thymine-1-ylmethyl)thymidine. Org. Biomol. Chem. (2007) 5, 1586–1594. [Abstract]
Ljungberg Pedersen, Søren and Nielsen, Poul. Stabilisation of nucleic acid secondary structures by oligonucleotides with an additional nucleobase; synthesis and incorporation of 2'-deoxy-2'-C-(2-(thymine-1-yl)ethyl)uridine. Org. Biomol. Chem., 2005, 3, 3570-3575. [Abstract]