Two carbocyclic analogues of LNA have been prepared by an RCM-based synthetic strategy in order to explore the importance of the ring constitution, the 2´-oxygen and of the puckering amplitude on LNA-mediated nucleic acid recognition.
Posters
Two carbocyclic locked nucleic acid analogues give structural information about the role of hydration in A-type duplexes (Nanna Albæk, Michael Petersen and Poul Nielsen) [Poster]
Publications
Albæk, Nanna; Petersen, Michael and Nielsen, Poul. Analogues of a Locked Nucleic Acid with three-Carbon 2'-,4'-Linkages: Synthesis by Ring-Closing Metathesis and Influence on Nucleic Acid Duplex Stability and Structure. J. Org. Chem., 2006, 71, 7731-7740. [Abstract]