I joined the Mandrup group in 2018 as a bachelor student, where I studied the regulation of a key-transcription factor involved in glucose-induced proliferation. As of February 2020, I was employed as a PhD student in the Mandrup group in the 4+4 enrollment program. My project focuses on pancreatic β-cell plasticity within the context of diet induced obesity and insulin-resistance in type 2 diabetes.
I aim to understand the transcriptional networks underlying the early adaptive and pathophysiological changes that occur within pancreatic β-cells in response to nutritional overload using single-cell omics and immunohistochemistry.
My studies will hopefully provide novel insight into transcriptional mechanisms and novel mediators that drive β-cell adaptation, some of which may constitute therapeutic targets for prevention and treatment of diabetes.