The laboratory studies mechanisms involved in cell cycle control of stem cell specification and cell-fate decisions during embryonic development (see Natarajan et al. 2017 Curr Op Gen Dev; Kolodziejczyk et al. 2015 Cell Stem Cell; Tuck et al. 2018 Life Science Alliance; Buettner*, Natarajan* et al 2015 Nature Biotechnology). We analyse embryonic stem cells and transgenic mouse models, using high-throughput approaches that include single-cell imaging, single-cell genomics (transcriptomics, chromatin accessibility, multi-omics), Flow cytometry and CRISPR/Cas9 genome editing to identify new regulators and mechanisms controlling cell-fate decisions. We also analyse and develop experimental and computational methods for analyses of bulk, single-cell omics datasets (see Chen, Natarajan and Teichmann 2017 BioRxiv; Buettner*, Natarajan* et al 2015 Nature Biotechnology; Svensson*, Natarajan* et al 2017 Nature Methods), and part of SDU eScience centre.
Additionally, we have a strong network of international experimental and computational collaborators. For more information on Natarajan group, please see the department's website or the Natarajan Laboratory.
Our laboratory is a core part of the Functional Genomics and Metabolism Unit, which hosts five independent research groups that perform a variety of basic and functional genomics research. We are based within the Department of Biochemistry and Molecular Biology at University of Southern Denmark, Odense which hosts >20 research groups. The unit and department offer an international working environment with state-of-the-art facilities for next generation sequencing, mouse generation, Flow cytometry, single-cell transcriptomics, Mass spectrometry, and National Bioimaging facility among others. We also have close ties to the Odense University Hospital (OUH).
Research Project and Role
You will be main driver of the multidisciplinary project to investigate transcriptional networks during cell cycle at single-cell level. This project involves deriving transgenic embryonic stem cells, mouse models using CRISPR-Cas9 and profiling using time-lapse microscopy and single-cell multi-omics profiling. You will also implement other experimental methods for bulk and single-cell analysis for the group.
We are looking for highly motivated and enthusiastic scientists with the following competences and experience:
• PhD in Life Science, preferable Developmental biology, Molecular biology or Systems Biology with strong expertise in either mouse models, transgenic stem cells and/or single-cell technologies
• Ideally one first author manuscript in relevant journal in the field.
• Strong communication and collaboration skills
• Excellent writing and oral communication skills in English
• Knowledge and experience with CRISPR-Cas9 system, flow cytometry, NGS and microscopy
• Experience with bulk and/or single-cell NGS data analysis
• Ability to work independently within a team of multi-disciplinary scientists
• A two-year post in first instance (further extendable) with a competitive salary and social benefits (e.g. Health coverage, parental leave, social security etc.)
• Access to state-of-the art tools, facilities and infrastructure and network of international collaborators.
• A stimulating and supportive international research environment
• Dedicated assistance and support with various practical, social, legal aspects (housing, visa, administration, tax etc), especially for international candidates through our international staff office (ISO) and department.
Informal queries can be made to Kedar Natarajan (email@example.com) or Susanne Mandrup (firstname.lastname@example.org).
We welcome letters of interest towards the position.
Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The application must be in English and include (only in PDF format):
1. Motivation letter (max. one page)
2. CV incl. education, work/research experience and skills relevant for the position.
3. Copy of PhD certificate. If awaiting PhD, provide a written statement from the supervisor.
4. List of publications
5. At least two letters of reference (with referee contact details and relationship). The referees may send the supporting letters directly to email@example.com, mentioning the candidate’s name and title of position in subject line.
Shortlisting may be used in the assessment process.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated.
To qualify you must have passed a PhD or equivalent. Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Further information for international applicants about entering and working in Denmark.