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Torben Barington

Torben Barington, Professor, Head of OPEN
Affiliation:
OPEN
Mail: Torben.Barington@rsyd.dk
Tel.: +45 65 41 35 70 / Mobile: +45 29 62 83 62
Area of interest: Basic and clinical immunology.
See Torben Barington's publication- and activity list here.

 

 

Competences: 
Medical specialist in clinical immunology, DMSc 

Own research projects:

  • The human immunglobulinrepertoire. Based on next-generation-sequencing and use of existing sequence materials, the human immunoglobulin repertoire and related molecular mechanisms rearrangement and somatic hypermutation are examined. The project is conducted in cooperation with MB Mike Beech Tofte Barnkob, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK and MSc., PhD, Tina Funck, Roskilde Hospital, etc. PMID: 25556246 PMID: 17371989 PMID: 17005006 PMID: 16133446 PMID: 14978139 PMID: 12694572 PMID: 11220626 PMID: 10225914 PMID: 9886390 PMID: 9601942 PMID: 9218844 PMID: 9234481 PMID: 8892635 PMID: 8783350 PMID: 7573850 PMID: 8039873 PMID: 7506919 PMID: 2493676 PMID: 2831268 PMID: 18592361
  • Mechanisms of varied expression of HLA-A and B alleles in human cells. We have discovered that HLA-A and -B alleles are not always expressed side by side on the surface of cells. In contrast to the blood cells, HLA-A is often constitutively expressed on certain stem cells, whereas the HLA-B is absent or weakly expressed until the cell is exposed to an inflammatory signal (eg. IFN-gamma). We have found that the difference is due to post-translational regulation and identified certain amino acids that are essential for a molecule expressed as HLA-A (high) or HLA-B (low). The project is conducted in cooperation with MSc. Christoffer Dellgren Department of Clinical Immunology, Odense University Hospital, etc. PMID: 26258424 PMID: 23349864 PMID: 20531935
  • Mechanisms involved in primary immune deficiencies. Immune Defects are often hereditary and elucidation of the underlying genetic defects and studies of the function of the patient's immune system provides both an understanding of the disease and sheds light on the immune system's normal physiology. Our studies include severe combined immune deficiency, antibody defects, and chronic granulomatous disease. PMID: 25551669 PMID: 25216719 PMID: 22924696 PMID: 18592361 PMID: 17230194 PMID: 15963052 PMID: 15610804 PMID: 15367430 PMID: 14971055 PMID: 12452841 PMID: 11014144 PMID: 9600318

Supervisor for:

  • Main supervisor for PhD-student, Maria Ormhøj. Department of Clinical Immunology, Odense University Hospital and the Center for Cancer Immunology, Massachusetts General Hospital (MGH), Boston, USA. Development of Chimeric Antigen Receptor T Cells Targeting the B-Cell Receptor Signalling Pathway. The project aims to develop and test a new form of cancer therapy with so-called CAR T cells directed against a molecule, which is shown on the surface of certain cancer cells.
  • Main supervisor for PhD-student, Leen Baudewijn. Department of Clinical Immunology, Odense University Hospital and the La Jolla Institute for Allergy and Immunology, La Jolla, California. Is the Reprogramming of CD4 T cells two CTL impaired in Celiac Disease? The project aims to investigate whether particular subsets of CD4 T-cells play a pathological role in celiac disease.
  • Main supervisor for PhD-student, Ane Landt Larsen. Department of Clinical Immunology, Odense University Hospital. Expression and signalling in the CD200-CD200R pathway. The project aims to study the function of the molecules CD200 and CD200 receptor function.
  • Supervisor for specialist registrar Nanna Holm. Department of Clinical Immunology, Odense University Hospital. Heavy chain repertoire of kappa and lambda positive B cells. The project investigates whether there are differences in antibodies' heavy chain when using kappa or lambda light chain.

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