Niklas Rye Jørgensen

Niklas Rye Jørgensen, Clinical Professor
OPEN & Department of Clinical Biochemistry, Copenhagen University Hospital 
Tel.: +45 38 63 24 56
Area of interest: Translational bone biology with special focus on the effects of loading and unloading on the skeleton, Use of bone turnover markers, Purinergic signalling in health and disease.
See Niklas Rye Jørgensen's publication- and activity list here.


  • Basic and translational bone research: Cellular and molecular biology of bone, in vivo models for the study of bone biology and the effects on the skeleton of physical activity and pharmacological treatment
  • Clinical drug trials
  • Biochemical analyses
  • Biomarkers of bone turnover

Own research projects:

  • Clinical use of bone turnover markers:
    • Establishment of robust Danish reference intervals for bone turnover markers
    • Stability of bone turnover markers in a routine clinical biochemistry lab
    • Bone turnover markers for monitoring of anti-osteoporotic treatment
    • Bone turnover markers for detection, prognosis and monitoring of malignant diseases involving the skeleton
  • The effects of loading and unloading on the skeleton:
    • The osteocyte in the regulation of bone metabolism
    • The role of purinergic receptors in mechanotransduction
  • Purinergic signalling in health and disease
    • Multiple myeloma – a role forpurinergic signalling in development of disease and bone lesions
    • P2Y12 receptor targeting platelet inhibitors – do they damage the bones?
    • P2X7 receptor antagonists in the treatment of bone diseases?
    • Genetic causes of osteoporosis – a role for P2 receptor polymorphisms?

Supervisor for:

Medical students, SDU, Søren Bønløkke Pedersen & Michael Schønemann Rand, OPEN  & Department of Clinical Biochemistry, Copenhagen University Hospital, OP_338 Bone turnover markers (BTMs) as predictors for treatment response, The aim of the study is to examine whether the value of baseline Bone Turnover Markers (BTMs) and changes in BTMs can predict the effect of anti-resorption treatment with osteoporosis patients. Using BTMs to monitor treatment response would potentially enable the clinician to identify non-responders within 3-6 months. 


PhD-student, Debbie Norring-Agerskov, OPEN, OP_304 Biochemical and genetic factors as predictors of mortality in hip fracture patients, The aim of this study is to investigate biochemical and genetic factors, which can predict the outcome in patients following a hip fracture. The knowledge obtained can be used to focus and individualize the treatment and thereby help reduce the risk of mortality.


PhD-student, Ditte Beck Jepsen, OPEN, OP_183 PTH and Vibration in Osteoporosis Study (PaVOS), The purpose of this project is to investigate the effects off combining standard parathyroid hormone (PTH) with Whole-body vibration (WBV) in the treatment of osteoporosis.

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