Methodologies and techniques

In our research we use classic clinical microbiological methods and modern molecular biology and protein chemistry. Culture based phenotypical (biochemical reaction patterns, in vitro resistance) characterisation of microorganisms is to a still higher extent supplemented with genetic analyses for the study of specific qualities like e.g. antibiotic resistance, virulence factors etc. ELISA, PCR, DNA sequencing and mass spectrometry are examples of laboratory techniques used in both routine and research connections. New technologies and new diagnostic applications are tested regularly. Registration of results obtained from the routine diagnostics form an important basis for evidence-based decisions.

An important area is relating clinical and epidemiological data with the microorganisms’ characteristic e.g. the distribution of strains with special qualities and/or special types.

For the testing of hypotheses we use in vitro assays that simulates clinical problems.

Through collaboration with other research units there we have access to further a number of other techniques and methods.