Research projects

Uropathogenesis in vitro:Investigation of E. coli persistence during recurrent cystitis using cell culture based infection models / Hans Jørn Kolmos, Thomas Emil Andersen

Recent research indicates that recurrent urinary tract infections may be caused by uropathogens surviving intracellularly in cells lining the bladder lumen. Protected inside cells, bacteria survive host response and antibiotic treatment and may re-emerge at later time points. We recently developed a human bladder cell infection model which replicates this pathogenesis pathway. In this project we study bacterial adhesion, morphology changes, intracellular survival as well the potential of traditional and novel drugs to interfere with this pathway and eradicate the intracellular bacterial reservoir. Cooperation with Department of Biochemistry and Molecular Biology, University of Southern Denmark. 

DORIS: Danish Observational Registry of Infectious Syndromes/ Thøger Gorm Jensen, Hans Jørn Kolmos

The project studies risk factors and prognosis in patients with severe socially obtained infection including sepsis, bacteraemia, and pneumonia. The examinations are mainly based on medical chart data, partly on data extract from some existing databases including Fyns Amts Patient registration system (FPAS), KMA’s laboratory information system (MADS), and the Odense Pharmacopoeia database (OPED). Cooperation with the Infection medical research unit SDU, Odense, Pharmacopoeia Database (OPED).

DANRES/Ulrik Stenz Justesen

DANRES is a working group, within the Danish Society of Clinical Microbiology, working with resistance and resistance surveillance and generating data for the Danish Integrated Antimicrobial Resistance Monitoring and Research Programme (DANMAP) and the European Antimicrobial Resistance Surveillance Network (EARS-Net). Cooperation with SSI, Departments of Clinical Microbiology in Denmark.

Antimicrobial susceptibility testing of anaerobic bacteria – development of a disk diffusion method/Ulrik Stenz Justesen

Departments of clinical microbiology around Europe are harmonizing their methods for antimicrobial susceptibility testing with disk diffusion. Currently there is no standardised disk diffusion method for anaerobic bacteria. Cooperation with ESCMID/EUCAST and Department of Clinical Microbiology, Centrallasarettet, Växjö.

Antimicriobial adjuvants – combining drugs against resistant bacteria/ Hans Jørn Kolmos, Janne Kudsk Klitgaard

The project studies different potential combinations of chemical compounds and/or natural drugs against resistant bacteria, as well as the underlying molecular mechanisms. Cooperation with the Department of Biochemistry and Molecular Biology, University of Southern Denmark.

Identification of small regulatory non-coding RNAs involved in antibiotic resistence/Janne Kudsk Klitgaard

The project studies the molecular mechanisms underlying the regulation of resistance genes expression by small regulatory non-coding RNAs. Department of Biochemistry and Molecular Biology, University of Southern Denmark. 

New material prevents device thrombosis/Hans Jørn Kolmos, Thomas Emil Andersen

In this project, our research unit collaborates with the industry in a cross-disciplinary project, aiming at the development of novel silicone-based materials which inhibit medical device-related infection. Nano-porous structures are polymerized inside silicone materials and these are subsequently loaded with active drugs which inhibit bacterial colonization. Among the drugs used for impregnation are antimicrobial peptides, which to a less extend than traditional drugs lead to antimicrobial resistance. The project is supported by the Danish National Advanced Technology Foundation and has a total budget of 21M DKK. Cooperation with BioModics, Chempilots, KU-farma, Novozymes.

Parasitic infections in Denmark: Diagnosis, Prevalence and Clinical significance / Gitte Nyvang Hartmeyer

The project is described in detail at: http://www.sdu.dk/om_sdu/institutter_centre/klinisk_institut/forskning/forskningsenheder/kliniskmikrobiologi/forskningsomraader/forskningsgruppen+for+parasitologi/forskningsprojekter

Transmission of bacterial diseases in the hospital and in the community /Marianne N. Skov, Marie Louise Slott Jensen, Anne Marie Rosendal Madsen

By use of whole genome DNA sequencing we map local transmission routes for a number of specific bacteria, including MRSA, Legionella pneumophila and Listeria monocytogenes. Cooperation with Hvidovre Hospital.

Genetic characterization of Enterococcus faecalis and Staphylococcus aureus strains that cause different manifestations of infection / Marianne Skov, Thomas Emil Andersen

The project uses whole genome DNA sequencing for detection and characterization of bacterial genes, that can be associated with characteristic disease manifestations of infection. Cooperation with clinical departments at Odense University Hospital and Department of Biochemistry and Molecular Biology at the University of Southern Denmark.