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PhD Projects

Most recdntly enrolled at the top

 

Individualized immunosuppression in kidney transplanted patients

Katrine Agergaard Sørensen

The PhD project aims to investigate if the anti-rejection treatment of patients with a kidney transplant can be improved, which might lead to fewer kidney rejections and a longer life span of transplanted kidneys.
The anti-rejection medicine tacrolimus is necessary to prevent kidney rejection and it is routine to measure tacrolimus in all patients’ blood at regular intervals and to adjust the dose accordingly to minimize adverse events and organ rejection. We want to investigate if tacrolimus measured inside the immune cells in the blood is a much better measure of how tacrolimus is affecting the body in order to individualize the treatment more in the future.
Main supervisor: Troels K. Bergmann

 

Iben Have Beck

 

Frederik Damsgaard Højsager

 

Lars Christian Lund

 

Ditte Bork Iversen

 

Ida Berglund Kuhlmann

 

 

Molecular mechanisms and drug transport in chemotherapy-induced peripheral neuropathy

Christina Mortensen

Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect to several chemotherapeutic drugs. There is currently no effective treatment of this side effect, leaving dose adjustment as the only possibility. Dose reduction limits the clinical efficacy of chemotherapy and cause a substantial reduction in treatment success. In the development of CIPN, sensory neurons of the peripheral nervous system are the cell type primarily affected by chemotherapeutic drugs. When dysfunctional, patients experience intolerable symptoms such as burning pain, numbness and sensory loss in hands and feet. These studies are expected to provide insight to the effect of chemotherapy on sensory neurons and investigate a novel biomarker for neuronal damage in a translational setting. The results may lead to discovery of novel drug targets to treat or prevent CIPN and ultimately may be useful in helping diagnose and monitor cancer patients with CIPN.
Main supervisor: Tore Bjerregaard Stage

Use of Real-World Data in screening for unknown drug effects and drug utilisation patterns within dermatology

Thomas Delvin

Monitoring of marketed drugs is an important part of the ongoing evaluation of the benefits and risks of drugs, and epidemiological analyzes of healthcare data have been proposed as an alternative to traditional side-effect monitoring.
In this project, epidemiologic screening of large healthcare databases will be applied to evaluate its use within dermatology, by conducting: 1) A study screening all dermatology drugs for adverse and beneficial effects, by using self-controlled designs and a nested  case-control analysis. 2) A study screening all marketed drugs for dermatological adverse outcomes using the same designs. 3) A comprehensive dermatology drug utilisation study screening for unexpected utilisation patterns.
Main supervisor: Jesper Hallas

 

Public Health Research in the Danish Community Pharmacy setting

Alaa Hassan Burghle

In Denmark, patients can go to any community pharmacy, with no appointment, and receive counselling on the safe and effective use of medication. In addition to the usual counselling a number of pharmaceutical care services are provided. This setting makes the community pharmacy an excellent data-provider for research projects as its platform can e.g. be used to collect information from patients on side effects not otherwise available through other means or targeting inappropriate use of medications through pharmaceutical care. With this PhD-thesis we aim to further explore and strengthen the possibility of conducting public health research projects in the Danish community pharmacy setting. We will achieve this through the conduct of three research projects, each utilizing different methods: a randomized controlled trial, a qualitative study, and a survey.
Main Supervisor: Anton Pottegård

 

The effect of initiating glucose-lowering treatment on the metabolism, transport and efficacy of other drugs among patients with type 2 diabetes

Ann-Cathrine Dalgård Dunvald

We have previously shown that initiation of glucose-lowering treatment leads to altered drug efficacy. To further elucidate this surprising but potentially impactful finding, we will assess the effect of glucose on the activity of important drug-metabolizing enzymes and transporters. Clinical pharmacokinetic studies in patients with type 2 diabetes will uncover the pharmacokinetic extent of this effect. Two different drug cocktails (one assessing drug-metabolizing enzyme activity and another assessing drug transport) will be administered to patients before and after initiation of the glucose-lowering drug metformin. This will uncover whether lowering of glucose causes altered drug metabolism and transport in patients with type 2 diabetes. Extensive register-based studies will elucidate the direct clinical impact of this effect. The knowledge obtained in these studies will help guide clinical decisions for managing comedication when initiating glucose-lowering treatment for patients with type 2 diabetes and provide a deeper understand of interindividual variability of drug metabolism.
Main Supervisor:  Tore Bjerregaard Stage

 

Implementation of personalized medicine in everyday practice: Preventing serious adverse reactions from chemotherapy.

Niels Herluf Paulsen

This project aims to substantially reduce the risk of serious adverse reactions in patients receiving 5-fluorouracil (5-FU) for cancer. The project will use a gene test to preemptively adjust the dose of 5-FU for each patient and hereby reducing the risk of risk of severe adverse reactions. This project may serve as a proof-of-concept for implementation of personalized medicine in everyday cancer treatment.
Main supervisor:  Per Damkier

Pharmacoepidemiological aspects of low-dose or off-label treatment with antipsychotics: Utilization and consequences

Mikkel Højlund

This PhD project uses register data to explore diagnoses associated with use of antipsychotics (psychiatric and non-psychiatric), and furthermore to investigate the potential acute and long-term risks associated with low-dose antipsychotic treatment.
Main supervisor: Jesper Hallas

 

Attitudes towards deprescribing in older patients with limited life expectancy: The perspective of patients, relatives, and health care professionals

Carina Lundby

This PhD project aims to explore attitudes towards deprescribing from the perspective of patients, relatives, and health care professionals, specifically focusing on older people with frailty and those approaching the last part of life. We will do this through systematic reviews and qualitative studies. Further, we will translate, cross-culturally adapt, and validate a questionnaire for exploring patient attitudes towards deprescribing. With this PhD project, we aim to get insight into what may facilitate and hinder deprescribing, and thus how to ultimately improve the uptake of deprescribing in clinical practice.
Main supervisor:  Anton Pottegård

 

CYP2D6 genotype-phenotype determination for improved personalized medicine

Trine Frederiksen

The objective of this project is to establish the clinical function level of the most frequent CYP2D6 alleles through population pharmacokinetic modelling of different CYP2D6 substrates. Ultimately, the aim is to find an optimal method for translating CYP2D6 genotypes into phenotypes for improved personalized medicine. The project is conducted in collaboration with H. Lundbeck A/S.
Main supervisor: Kim Brøsen
Co-supervisor: Tore Bjerregaard Stage