List of publications: Danish 100 year-olds

Frailty and Associated Factors among Centenarians in the 5-COOP Countries.
Herr M, Jeune B, Fors S, Andersen-Ranberg K, Ankri J, Arai Y, Cubaynes S, Santos-Eggimann B, Zekry D, Parker M, Saito Y, Herrmann F, Robine JM; 5-COOP group.
Gerontology. 2018 Jul:1-11. [Epub ahead of print] Pubmed abstract

Improvement in Activities of Daily Living among Danish Centenarians?

Rasmussen SH, Thinggaard M, Højgaard MB, Jeune B, Christensen K, Andersen-Ranberg K.
J Gerontol A Biol Sci Med Sci. 2018 Jul;73(8):1125-1131. Pubmed abstract

Cohort profile: The 1895, 1905, 1910 and 1915 Danish Birth Cohort Studies. Secular trends in the health and functioning in the very old. 
Rasmussen SH, Andersen-Ranberg K, Thinggaard M, Jeune B, Skytthe A, Christiansen L, Vaupel JW, McGue M, Christensen K.
Int J Epidemiol. 2017 Dec;46(6):1746-1746j. Pubmed abstract

Changes in Drug Use and Polypharmacy After the Age of 90: A Longitudinal Study of the Danish 1905 Cohort.

Wastesson JW, Oksuzyan A, von Bornemann Hjelmborg J, Christensen K.

J Am Geriatr Soc. 2017 Jan;65(1):160-164. Pubmed abstract


Survival Prognosis in Very Old Adults.
Thinggaard M, McGue M, Jeune B, Osler M, Vaupel JW, Christensen K.
J Am Geriatr Soc 2016;64:81-88. Pubmed abstract

Health and function assessments in two adjacent Danish birth cohorts of centenarians: Impact of design and methodology.
Vestergaard S, Andersen-Ranberg K, Skytthe A, Christensen K, Robine JM, Jeune B.
Eur J Ageing
2016;13:15-23. Pubmed abstract

The Danish Centenarian Program: Cardiovascular diseases in Danish Centenarians.
Andersen-Ranberg K, Christensen K, Jeune B.
Eur Geriatr Med. 2014 Sep;5:Suppl 1, p.S15.

Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals
Nygaard M, Lindahl-Jacobsen R, Soerensen M et al.
Exp Gerontol 2014;57:41-46. Pubmed abstract

Cardiovascular diseases are largely underreported in Danish centenarians.
Andersen-Ranberg K, Fjederholt KT, Madzak A, Nybo M, Jeune B.
Age Ageing
2013;42:249-53. Pubmed abstract

Optimism and survival: does an optimistic Outlook predict better survival at advanced ages? A twelve-year follow-up of Danish nonagenarians.
Engberg H, Jeune B, Andersen-Ranberg K, Martinussen T, Vaupel JW, Christensen K.
Aging Clin Exp Res 2013;25:517-25. Pubmed abstract

Centenarians today: New insights on selection from the 5-COOP study.
Robine JM, Cheung SL, Saito Y, Jeune B, Parker MG, Herrmann FR.
Curr Gerontol Geriatric Res 2010;120354. Pubmed abstract

Is the relationship between BMI and mortality increasingly U-shaped with advancing age? A 10-year follow-up of persons aged 70-95 years.
Thinggaard M, Jacobsen R, Jeune B, Martinussen T, Christensen K.
J Gerontol A Biol Sci Med 2010;65:526-31. Pubmed abstract

Ageing populations: the challenges ahead.
Christensen K, Doblhammer G, Rau R, Vaupel JW.
Lancet. 2009;374:1196-208. Pubmed abstract

Centenarians - a useful model for healthy aging?
A 29-year follow-up of hospitalizations among 40,000 Danes born in 1905.
Engberg H, Oksuzyan A, Jeune B, Vaupel JW, Christensen K.
Aging cell 2009;8:270-76. Pubmed abstract

Publications 1996-2008:

  1. Christensen K, McGue M, Petersen I, Jeune B, Vaupel JW.
    Exceptional longevity does not result in excessive levels of disability.
    Proc Natl Acad Sci U S A 2008;105:13274-79.
  2. Engberg H, Christensen K, Andersen-Ranberg K, Jeune B.
    Cohort changes in cognitive function among Danish centenarians. A comparative study of 2 birth cohorts born in 1895 and 1905.
    Dement Geriatr Cogn Disord. 2008;26(2):153-60. Pubmed abstract
  3. Hartvigsen J, Christensen K.
    Pain in the back and neck are with us until the end: A nationwide interview-based survey of Danish 100-year-olds.
    Spine. 2008 Apr;33(8):909-13. Pubmed abstract
  4. Kimura M, Cherkas LF, Kato BS, Demissie S, Hjelmborg JB, Brimacombe M, Cupples A, Hunkin JL, Gardner JP, Lu X, Cao X, Sastrasinh M, Province MA, Hunt SC, Christensen K, Levy D, Spector TD, Aviv A.
    Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm.
    PLoS Genet. 2008 Feb;4(2):e37. Pubmed abstract
  5. Kimura M, Hjelmborg JV, Gardner JP, Bathum L, Brimacombe M, Lu X, Christiansen L, Vaupel JW, Aviv A, Christensen K.
    Telomere length and mortality: A study of leukocytes in elderly Danish twins.
    Am J Epidemiol. 2008 Apr 1;167(7):799-806. Pubmed abstract
  6. Lambert JC, Ferreira S, Gussekloo J, Christiansen L, Brysbaert G, Slagboom E, Cottel D, Petit T, Hauw JJ, DeKosky ST, Richard F, Berr C, Lendon C, Kamboh MI, Mann D, Christensen K, Westendorp R, Amouyel P.
    Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly.
    Mol Psychiatry. 2007 Sep;12(9):870-80. Pubmed abstract
  7. McGue M, Christensen K.
    Social activity and healthy aging: a study of aging Danish twins.
    Twin Res Hum Genet. 2007 Apr;10(2):255-65. Pubmed abstract
  8. Franceschi C, Bezrukov V, Blanché H, Bolund L, Christensen K, de Benedictis G, Deiana L, Gonos E, Hervonen A, Yang H, Jeune B, Kirkwood TB, Kristensen P, Leon A, Pelicci PG, Peltonen L, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Sikora E, Slagboom PE, Spazzafumo L, Stazi MA, Toussaint O, Vaupel JW.
    Genetics of healthy aging in Europe: The EU-integrated project GEHA (GEnetics of Healthy Aging).
    Ann N Y Acad Sci. 2007 Apr;1100:21-45. Review. Pubmed abstract
  9. Andersen FK, Christensen K, Frederiksen H.
    Self-rated health and age: A cross-sectional and longitudinal study of 11,000 Danes aged 45-102.
    Scand J Public Health. 2007;35(2):164-71. Pubmed abstract
  10. Bathum L, von Bornemann Hjelmborg J, Christiansen L, McGue M, Jeune B, Christensen K.
    Methylenetetrahydrofolate reductase 677C>T and methionine synthase 2756A>G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians.
    J Gerontol A Biol Sci Med Sci. 2007 Feb;62(2):196-201. Pubmed abstract
  11. Hartvigsen J, Christensen K.
    Active lifestyle protects against incident low back pain in seniors: a population-based 2-year prospective study of 1387 Danish twins aged 70-100 years.
    Spine 2007 Jan;32(1):76-81. Pubmed abstract
  12. Tan Q, Christiansen L, Brasch-Andersen C, Zhao JH, Li S, Kruse TA, Christensen K.
    Retrospective analysis of main and interaction effects in genetic association studies of human complex traits.
    BMC Genetics 2007 Oct 16; 8:70. Pubmed abstract
  13. Christiansen L, Tan Q, Iachina M, Bathum L, Kruse TA, McGue M, Christensen K.
    Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population.
    Biol Psychiatry. 2007 Jan 15;61(2):223-30. Pubmed abstract
  14. Graakjaer J, Londono-Vallejo JA, Christensen K, Kølvraa S.
    The pattern of chromosome-specific variations in telomere length in humans shows signs of heritability and is maintained through life.
    Ann N Y Acad Sci. 2006 May;1067:311-6. Pubmed abstract
  15. Singh R, Kølvraa S, Bross P, Christensen K, Gregersen N, Tan Q, Jensen UB, Eiberg H, Rattan SI.
    Heat-shock protein 70 genes and human longevity: A view from Denmark.
    Ann N Y Acad Sci. 2006 May;1067:301-8. Pubmed abstract
  16. Hartvigsen J, Frederiksen H, Christensen K.
    Physical and mental function and incident low back pain in seniors: a population-based two-year prospective study of 1387 Danish Twins aged 70 to 100 years.
    Spine. 2006 Jun 15;31(14):1628-32. Pubmed abstract
  17. Christiansen L, Brasch-Andersen C, Bathum L, Kruse TA, Christensen K.
    A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival.
    Mech Ageing Dev. 2006 Jul;127(7):597-9. Pubmed abstract
  18. Bischoff C, Petersen HC, Graakjaer J, Andersen-Ranberg K, Vaupel JW, Bohr VA, Kølvraa S, Christensen K.
    No association between telomere length and survival among the elderly and oldest old.
    Epidemiology. 2006 Mar;17(2):190-4. Pubmed abstract
  19. Bathum L, Christiansen L, Jeune B, Vaupel J, McGue M, Christensen K.
    Apolipoprotein E genotypes: relationship to cognitive functioning, cognitive decline, and survival in nonagenarians.
    JAGS 2006 Apr;54(4):654-8. Pubmed abstract
  20. Tan Q, Christiansen L, Bathum L, Li S, Kruse TA, Christensen K.
    Genetic association analysis of human longevity in cohort studies of elderly subjects: an example of the PON1 gene in the Danish 1905 birth cohort.
    Genetics 2006 Mar;172(3):1821-8. Pubmed abstract
  21. Tan Q, Kruse TA, Christensen K.
    Design and analysis in genetic studies of human ageing and longevity.
    Ageing Research Reviews 2006 Nov; 5(4): 371-87. Pubmed abstract
  22. Christensen K, Johnson TE, Vaupel JW.
    The quest for genetic determinants of human longevity: Challenges and insights.
    Nature Reviews Genetics 2006 Jun;7(6):436-48. Pubmed abstract
  23. Hjelmborg JvB, Iachine I, Skytthe A, Vaupel JW, McGue M, Koskenvuo M, Kaprio J, Pedersen NL, Christensen K.
    Genetic influence on human lifespan and longevity.
    Hum Genet. 2006 Apr;119(3):312-21. Pubmed abstract
  24. Frederiksen H, Hjelmborg J, Mortensen J, McGue M, Vaupel JW, Christensen K.
    Age trajectories of grip strength: Cross-sectional and longitudinal data among 8,342 Danes aged 46 to 102.
    Ann Epidemiol. 2006 Jul;16(7):554-62. Pubmed abstract
  25. Bladbjerg EM, de Maat MP, Christensen K, Bathum L, Jespersen J, Hjelmborg J.
    Genetic influence on thrombotic risk markers in the elderly - A Danish twin study.
    J Thromb Haemost. 2006 Mar;4(3):599-607. Pubmed abstract
  26. Jeune B, Skytthe A, Cournil A, Greco V, Gampe J, Berardelli M, Andersen-Ranberg K, Passarino G, Debenedictis G, Robine JM.
    Handgrip strength among nonagenarians and centenarians in three European regions.
    J Gerontol A Biol Sci Med Sci. 2006 Jul;61(7):707-12. Pubmed abstract
  27. Bathum L, Christiansen L, Tan Q, Vaupel J, Jeune B, Christensen K.
    No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians.
    Eur J Hum Genet. 2005 Oct;13(10):1154-8. Pubmed abstract
  28. Hartvigsen J, Pedersen H C, Frederiksen H, Christensen K.
    Small effects of genetic factors on neck pain in old age. A study of 2,108 Danish twins 70 years of age and older.
    Spine 2005 Jan 15;30(2):206-8. Pubmed abstract
  29. Aviv A, Shay J, Christensen K, Wright W.
    The longevity gender gap: Are telomeres the explanation?
    Sci Aging Knowledge Environ. 2005 Jun 8;2005(23):pe16. Review. Pubmed abstract
  30. Tan Q, Christiansen L, Bathum L, Zhao JH, Yashin AI, Vaupel JW, Christensen K, Kruse TA.
    Estimating haplotype relative risks on human survival in population-based association studies.
    Human Heredity 2005;59(2):88-97. Pubmed abstract
  31. Bischoff C, Graakjaer J, Petersen HC, Jeune B, Bohr VA, Koelvraa S, Christensen K.
    Telomere length among the elderly and oldest-old.
    Twin Research and Human Genetics 2005 Oct;8(5):425-32. Pubmed abstract
  32. Bischoff C, Graakjaer J, Petersen HC, Hjelmborg JvB, Vaupel JW, Bohr VA, Koelvraa S, Christensen K.
    The heritability of telomere length among the elderly and oldest-old.
    Twin Research and Human Genetics 2005 Oct;8(5):433-9. Pubmed abstract
  33. Rohr G, Stovring H, Christensen K, Gaist D, Nybo H, Kragstrup J.
    Characteristics of middle-aged and elderly women with urinary incontinence.
    Scand J Prim Health Care 2005 Dec;23(4):203-8. Pubmed abstract
  34. Tan Q, Christiansen L, Christensen K, Kruse TA, Bathum L.
    Apolipoprotein E genotype frequency patterns in aged Danes as revealed by logistic regression models.
    European Journal of Epidemiology 2004;19(7):651-6. Pubmed abstract
  35. Christiansen L, Petersen HC, Bathum L, Frederiksen H, McGue M, Christensen K.
    The catalase -262C/T promoter polymorphism and aging phenotypes.
    J Gerontol A Biol Sci Med Sci 2004 Sep;59(9):B886-9. Pubmed abstract
  36. Christiansen L, Bathum L. Frederiksen H, Christensen K.
    Paraoxonase 1 polymorphisms and survival.
    European Journal of Human Genetics 2004 Oct;12(10):843-7. Pubmed abstract
  37. Andersen-Ranberg K, Høier-Madsen M, Wiik A, Jeune B, Hegedus L.
    High prevalence of autoantibodies among Danish centenarians.
    Clin Exp Immunol. 2004 Oct;138(1):158-63. Pubmed abstract
  38. Bruunsgaard H, Benfield TL, Andersen-Ranberg K, Hjelmborg JB, Pedersen AN, Schroll M, Pedersen BK, Jeune B.
    The tumor necrosis factor alpha -308G>A polymorphism is associated with dementia in the oldest old.
    J Am Geriatr Soc. 2004 Aug;52(8):1361-6. Pubmed abstract
  39. Christiansen L, Bathum L, Andersen-Ranberg K, Jeune B, Christensen K.
    Modest implication of interleukin-6 promoter polymorphisms in longevity.
    Mech Ageing Dev. 2004 May;125(5):391-5. Pubmed abstract
  40. Bruunsgaard H, Andersen-Ranberg K, Hjelmborg JB, Pedersen BK, Jeune B.
    Elevated levels of tumor necrosis factor alpha and mortality in centenarians.
    Am J Med. 2003 Sep;115(4):278-83. Pubmed abstract
  41. Nybo H, Petersen HC, Gaist D, Jeune B, Andersen K, McGue M, Vaupel JW, Christensen K.
    Predictors of mortality in 2,249 nonagenarians - the Danish 1905-Cohort Survey.
    J Am Geriatr Soc. 2003 Oct;51(10):1365-73. Pubmed abstract
  42. Sandmand M, Bruunsgaard H, Kemp K, Andersen-Ranberg K, Schroll M, Jeune B.
    High circulating levels of tumor necrosis factor-alpha in centenarians are not associated with increased production in T lymphocytes.
    Gerontology. 2003 May-Jun;49(3):155-60. Pubmed abstract
  43. Bruunsgaard H, Østergaard L, Andersen-Ranberg K, Jeune B, Pedersen BK.
    Proinflammatory cytokines, antibodies to Chlamydia pneumoniae and age-associated diseases in Danish centenarians: Is there a link?
    Scand J Infect Dis. 2002;34(7):493-9. Pubmed abstract
  44. Tan Q, Yashin AI, Bladbjerg EM, de Maat MP, Andersen-Ranberg K, Jeune B, Christensen K, Vaupel JW.
    A case-only approach for assessing gene by sex interaction in human longevity.
    J Gerontol A Biol Sci Med Sci. 2002 Apr;57(4):B129-33. Pubmed abstract
  45. Frederiksen H, McGue M, Jeune B, Gaist D, Nybo H, Skytthe A, Vaupel JW, Christensen K.
    Do children of long-lived parents age more successfully?
    Epidemiology 2002 May;13:334-9. Pubmed abstract
  46. Frederiksen H, McGue M, Jeune B, Gaist D, Nybo H, Skytthe AE, Vaupel JW, Christensen K.
    Har børn af længelevende forældre en bedre alderdom?
    [Do children of long-lived parents age more successfully?] Pubmed abstract
    Ugeskr Laeger 2002 Oct 21; 164(43):5027-32. (invited parallel publication)
  47. Andersen K, Nybo H, Gaist D, Petersen HC, McGue M, Jeune B, Vaupel JW, Christensen K.
    Cognitive impairment and mortality among nonagenarians: The Danish 1905 cohort survey.
    Dement Geriatr Cogn Disord. 2002;13(3):156-63. Pubmed abstract
  48. Rosholm JU, Nybo H, Andersen Ranberg K, Himmelstrup B, Skjelbo E, Christensen K, Gram LF.
    Hyponatraemia in very old nonhospitalised people: Association with drug use.
    Drugs Aging. 2002;19(9):685-93. Pubmed abstract
  49. Bathum L, Christiansen L, Nybo H, Ranberg KA, Gaist D, Jeune B, Petersen NE, Vaupel J, Christensen K.
    Association of mutations in the hemochromatosis gene with shorter life expectancy.
    Arch Intern Med. 2001 Nov 12;161(20):2441-4. Pubmed abstract
  50. Tan Q, Yashin AI, Bladbjerg EM, de Maat MP, Andersen-Ranberg K, Jeune B, Christensen K, Vaupel JW.
    Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity.
    Exp Gerontol. 2001 Aug;36(8):1303-15. Pubmed abstract
  51. Varcasia O, Garasto S, Rizza T, Andersen-Ranberg K, Jeune B, Bathum L, Andreev K, Tan Q, Yashin AI, Bonafè M, Franceschi C, De Benedictis G.
    Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locus.
    Ann Hum Genet. 2001 Jul;65(Pt 4):371-6. Pubmed abstract
  52. Andersen-Ranberg K, Schroll M, Jeune B.
    Healthy centenarians do not exist, but autonomous centenarians do: A population-based study of morbidity among Danish centenarians.
    J Am Geriatr Soc. 2001 Jul;49(7):900-8. Pubmed abstract
  53. Andersen-Ranberg K, Vasegaard L, Jeune B.
    Dementia is not inevitable: A population-based study of Danish centenarians.
    J Gerontol B Psychol Sci Soc Sci. 2001 May;56(3):P152-9. Pubmed abstract
  54. Nybo H, Gaist D, Jeune B, McGue M, Vaupel JW, Christensen K.
    Functional status and self-rated health in 2,262 nonagenarians: The Danish 1905 Cohort Survey.
    J Am Geriatr Soc. 2001 May;49(5):601-9. Pubmed abstract
  55. Nybo H, Gaist D, Jeune B, Bathum L, McGue M, Vaupel JW, Christensen K.
    The Danish 1905 cohort: A genetic-epidemiological nationwide survey.
    J Aging Health. 2001 Feb;13(1):32-46. Pubmed abstract
  56. Christensen K, Kristiansen M, Hagen-Larsen H, Skytthe A, Bathum L, Jeune B, Andersen-Ranberg K, Vaupel JW, Orstavik KH.
    X-linked genetic factors regulate hematopoietic stem-cell kinetics in females.
    Blood. 2000 Apr;95(7):2449-51. Pubmed abstract
  57. Jeune B, Andersen-Ranberg K.
    Hvad kan vi lære af hundredårige?
    [What can be learned from centenarians?]
    Ugeskr Laeger. 1999;161(46):6321-5. Danish. 
  58. Andersen-Ranberg K, Jeune B, Høier-Madsen M, Hegedüs L.
    Thyroid function, morphology and prevalence of thyroid disease in a population-based study of Danish centenarians.
    J Am Geriatr Soc. 1999 Oct;47(10):1238-43. Pubmed abstract
  59. Bladbjerg EM, Andersen-Ranberg K, de Maat MP, Kristensen SR, Jeune B, Gram J, Jespersen J.
    Longevity is independent of common variations in genes associated with cardiovascular risk.
    Thromb Haemost. 1999 Sep;82(3):1100-5. Pubmed abstract
  60. Bruunsgaard H, Andersen-Ranberg K, Jeune B, Pedersen AN, Skinhøj P, Pedersen BK.
    A high plasma concentration of TNF-alpha is associated with dementia in centenarians.
    J Gerontol A Biol Sci Med Sci. 1999 Jul;54(7):M357-64. Pubmed abstract
  61. Andersen-Ranberg K, Christensen K, Jeune B, Skytthe A, Vasegaard L, Vaupel JW.
    Declining physical abilities with age: a cross-sectional study of older twins and centenarians in Denmark.
    Age Ageing. 1999 Jul;28(4):373-7. Pubmed abstract
  62. Kristensen SR, Andersen-Ranberg K, Bathum L, Jeune B.
    Factor V Leiden and venous thrombosis in Danish centenarians.
    Thromb Haemost. 1998 Nov;80(5):860-1. Pubmed abstract
  63. Andersen HR, Jeune B, Nybo H, Nielsen JB, Andersen-Ranberg K, Grandjean P.
    Low activity of superoxide dismutase and high activity of glutathione reductase in erythrocytes from centenarians.
    Age Ageing. 1998 Sep;27(5):643-8. Pubmed abstract
  64. Nybo M, Olsen H, Jeune B, Andersen-Ranberg K, Holm Nielsen E, Svehag SE.
    Increased plasma concentration of serum amyloid P component in centenarians with impaired cognitive performance.
    Dement Geriatr Cogn Disord. 1998 May-Jun;9(3):126-9. Pubmed abstract
  65. Bathum L, Andersen-Ranberg K, Boldsen J, Brøsen K, Jeune B.
    Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevity. Role of CYP2D6 and CYP2C19 in longevity.
    Eur J Clin Pharmacol.1998 Jul;54(5):427-30. Pubmed abstract
  66. Olsen H, Jeune B, Andersen-Ranberg K.
    Hundredårige på Fyn.
    [Centenarians in the county of Funen. Morbidity and functional capacity].
    Ugeskr Laeger. 1996;158(51):7397-401. Danish. Pubmed abstract

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