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Twin research


Genetics and Epigenetics - Aging and Longevity

Study on the association between variation in the genome, epigenome and transcriptome associated with longevity and age-related traits. We use DNA from middle-aged and older twins, combined with survey data regarding a variety of traits related to health and functional capacity.
| 2019-2022 | Project description


NorTwinCan: Nordic Twin Study of Cancer

NorTwinCan is the largest twin study in the world available for the research of heritability and familial risks of cancers such as prostata, breast, ovarian, and colon cancer. 
| 2002-2025 | Project description


Female sex hormones and cognition in middle-aged and elderly Danish twins

PhD Project: Women have higher lifetime risk of developing AD than men. Additionally, women with AD tend to have lower cognitive function compared to men with AD. These sex differences raise the question of female sex hormones’ influence on cognition and risk of dementia. The aim is to study the association between female sex hormones and cognition in mid- and late life in Danish twins. 
| 2017-2020 | Project description


Skin ageing: Genetic and environmental factors

The main objective is to investigate the degree of genetic and environmental influence on the visual aging of facial skin and appearance. This is examined through clinical photographs, lifestyle questionnaires and outer skin measurements in twins. The project involved 100 female twins aged 60 to 80 years. 
| 2004-2005 | Project description


DaTRIS : The Danish Twin Registry Infrastructure Study*

DaTRIS is an umbrella project consisting of a number of sub-projects for which biological material has been collected as well as health data from approx. 14,000 monozygotic and dizygotic Danish twins born during the years 1931-69. 
| 2008-2011 | Project description


MADT 98 : Middle Aged Danish Twins*

Survey on Danish twins born 1931-52, in which 4,314 twins participated. The study included interviews, physical measurements and tests as well as blood samples. In 2008/11 a 10-year follow-up was conducted. 
| 1998 and 2008-2011 | Project description


Geminakar I & II*
|: Insulin resistance, abdominal adipositas and cardiovascular risk factors

The first round of this project in 1998 included healthy Danish twins with no diagnosis of diabetes or cardiovascular disease. In the second round of GEMINAKAR the importance of sleep for the development of metabolic syndrome and type 2 diabetes were investigated, alone and in interaction with the genes. 
| 1998 and 2008 | Project description


LSADT : Longitudinal Study of Aging Danish Twins*

Longitudinal study of about 5.000 Danish twins born before 1931. The purpose of the studies was to elucidate reasons for variation in longevity, health, diseases, loss of functional abilities and intellectual skills among the elderly and very oldest Danes. 
| 1995-2007 | Project description